TY  - JOUR
TI  - Structure-Based Molecular Docking Studies toward 
Exploring Phytoestrogen against Breast Cancer
AB  - Objectives: Breast cancer (BCa) remains the world’s second biggest cause of cancer death. This occurs as a result of 
unregulated cell development and can be metastasized to other parts of the human. Estrogen receptor alpha is the 
renowned target that has piqued the interest of researchers to target BCa. FlexX molecular docking technique was used 
to predict the aspects of interaction, affinities energy, and orientation of natural compounds in the protein site. Phytoconstituents have a vital role in anticancer activities due to their important scaffolds, which may offer more effective 
and reduced costs and side effects than synthetic drugs. The present study aims to identify new anticancer agents from 
natural and dietary compounds with lesser adverse effects.
Methods: To accomplish this, we implemented with the help of molecular docking approaches using FlexX for predicting the features of bioactive phytocompounds from natural products and evaluating targeted binding affinity energy.
Results: Our results confirm that among various natural compounds, daidzein has the best docking score in the ten 
compounds compared with the standard drug cytarabine.
Conclusion: Our study suggests that daidzein is a potent ligand for ERα BCa among all and can be further investigated through in vitro and in vivo studies.
AU  - Sankar, Mirunalini
AU  - Ramakrishnan, Elancheran
AU  - LENIN, MARUTHANILA V.L
DO  - 10.14744/ejmo.2022.43656
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 142
EP  - 149
DB  - TRDizin
UR  - http://search/yayin/detay/531296
ER  -