Role of Inflammation in Benign Salivary Gland Tumor 
Etiopathogenesis: An Evaluation through the Blood 
Inflammatory Biomarkers

IACONETTA, GIORGIO; Califano, Luigi; barone, simona; Bonavolontà, Paola; GALDIERO, MARIA ROSARIA; Dell'Aversana Orabona, Giovanni; Cristinziano, Leonardo; Abbate, Vincenzo; Modestino, Luca

doi:10.14744/ejmo.2022.29857

Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers

Vincenzo ABBATE, (Department of Neurosciences, Maxillofacial Surgery Unit, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples NA, Italy)

Simona BARONE, (Department of Neurosciences, Maxillofacial Surgery Unit, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples NA, Italy)

Giovanni Dell Aversana ORABONA, (Department of Neurosciences, Maxillofacial Surgery Unit, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples NA, Italy)

Paola BONAVOLONT, (Department of Neurosciences, Maxillofacial Surgery Unit, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples NA, Italy)

Maria Rosaria GALDIERO, (Department of Translational Medical Sciences (DiSMeT), Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples NA, Italy)

Leonardo CRISTINZIANO, (Department of Translational Medical Sciences (DiSMeT), Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples NA, Italy)

Luca MODESTINO, (Department of Translational Medical Sciences (DiSMeT), Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples NA, Italy)

Giorgio IACONETTA, (Department of Medicine, Surgery and Odontoiatrics, Neurosurgery Unit, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy)

Luigi CALİFANO (Department of Neurosciences, Maxillofacial Surgery Unit, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples NA, Italy)

Eurasian Journal of Medicine and Oncology

1 0

Yıl: 2022 Cilt: 6 Sayı: 2 Sayfa Aralığı: 150 - 155 Metin Dili: İngilizce DOI: 10.14744/ejmo.2022.29857 İndeks Tarihi: 06-07-2022

Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers

Öz:

Objectives: To investigate the immune inflammatory profile in patients affected by benign salivary gland tumors (SGTs) by evaluating the blood inflammatory biomarkers. Methods: A retrospective chart review was performed between January 2015 and April 2020, collecting the data of all patients admitted for benign SGTs in our maxillofacial surgery unit. A total of 191 patients were divided into two groups: 94 with Warthin’s tumor (WT group) and 97 with pleomorphic adenoma (PA group) at histological diagnosis. The third group consisted of 90 patients randomly selected as the control group (C group). Results: The most relevant correlations were found by analyzing the values of some inflammatory biomarkers among the three groups. The neutrophil-to-lymphocyte ratio was found significantly higher in patients in the PA (p<0.005) and WT (p<0.001) groups than in patients in the C group. Similarly, the systemic immune-inflammation index was found significantly higher in patients in the PA and WT (p<0.005) groups than in patients in the C group. The platelet-tolymphocyte ratio was significantly higher in patients in the PA group than in patients in the WT (p<0.05) and C groups (p<0.05). Conclusion: In both WT and PA groups, the inflammatory status of the patients was found altered. Thus, inflammation and the immune system seem to have a role in the genesis of these benign salivary neoplasms whose etiopathogenesis is still debated.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Abbate V, barone s, Dell'Aversana Orabona G, Bonavolontà P, GALDIERO M, Cristinziano L, Modestino L, IACONETTA G, Califano L (2022). Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. , 150 - 155. 10.14744/ejmo.2022.29857
Chicago	Abbate Vincenzo,barone simona,Dell'Aversana Orabona Giovanni,Bonavolontà Paola,GALDIERO MARIA ROSARIA,Cristinziano Leonardo,Modestino Luca,IACONETTA GIORGIO,Califano Luigi Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. (2022): 150 - 155. 10.14744/ejmo.2022.29857
MLA	Abbate Vincenzo,barone simona,Dell'Aversana Orabona Giovanni,Bonavolontà Paola,GALDIERO MARIA ROSARIA,Cristinziano Leonardo,Modestino Luca,IACONETTA GIORGIO,Califano Luigi Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. , 2022, ss.150 - 155. 10.14744/ejmo.2022.29857
AMA	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. . 2022; 150 - 155. 10.14744/ejmo.2022.29857
Vancouver	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. . 2022; 150 - 155. 10.14744/ejmo.2022.29857
IEEE	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L "Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers." , ss.150 - 155, 2022. 10.14744/ejmo.2022.29857
ISNAD	Abbate, Vincenzo vd. "Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers". (2022), 150-155. https://doi.org/10.14744/ejmo.2022.29857

APA	Abbate V, barone s, Dell'Aversana Orabona G, Bonavolontà P, GALDIERO M, Cristinziano L, Modestino L, IACONETTA G, Califano L (2022). Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. Eurasian Journal of Medicine and Oncology, 6(2), 150 - 155. 10.14744/ejmo.2022.29857
Chicago	Abbate Vincenzo,barone simona,Dell'Aversana Orabona Giovanni,Bonavolontà Paola,GALDIERO MARIA ROSARIA,Cristinziano Leonardo,Modestino Luca,IACONETTA GIORGIO,Califano Luigi Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. Eurasian Journal of Medicine and Oncology 6, no.2 (2022): 150 - 155. 10.14744/ejmo.2022.29857
MLA	Abbate Vincenzo,barone simona,Dell'Aversana Orabona Giovanni,Bonavolontà Paola,GALDIERO MARIA ROSARIA,Cristinziano Leonardo,Modestino Luca,IACONETTA GIORGIO,Califano Luigi Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. Eurasian Journal of Medicine and Oncology, vol.6, no.2, 2022, ss.150 - 155. 10.14744/ejmo.2022.29857
AMA	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. Eurasian Journal of Medicine and Oncology. 2022; 6(2): 150 - 155. 10.14744/ejmo.2022.29857
Vancouver	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers. Eurasian Journal of Medicine and Oncology. 2022; 6(2): 150 - 155. 10.14744/ejmo.2022.29857
IEEE	Abbate V,barone s,Dell'Aversana Orabona G,Bonavolontà P,GALDIERO M,Cristinziano L,Modestino L,IACONETTA G,Califano L "Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers." Eurasian Journal of Medicine and Oncology, 6, ss.150 - 155, 2022. 10.14744/ejmo.2022.29857
ISNAD	Abbate, Vincenzo vd. "Role of Inflammation in Benign Salivary Gland Tumor Etiopathogenesis: An Evaluation through the Blood Inflammatory Biomarkers". Eurasian Journal of Medicine and Oncology 6/2 (2022), 150-155. https://doi.org/10.14744/ejmo.2022.29857