TY  - JOUR
TI  - Role of Inflammation in Benign Salivary Gland Tumor 
Etiopathogenesis: An Evaluation through the Blood 
Inflammatory Biomarkers
AB  - Objectives: To investigate the immune inflammatory profile in patients affected by benign salivary gland tumors 
(SGTs) by evaluating the blood inflammatory biomarkers.
Methods: A retrospective chart review was performed between January 2015 and April 2020, collecting the data of 
all patients admitted for benign SGTs in our maxillofacial surgery unit. A total of 191 patients were divided into two 
groups: 94 with Warthin’s tumor (WT group) and 97 with pleomorphic adenoma (PA group) at histological diagnosis. 
The third group consisted of 90 patients randomly selected as the control group (C group).
Results: The most relevant correlations were found by analyzing the values of some inflammatory biomarkers among 
the three groups. The neutrophil-to-lymphocyte ratio was found significantly higher in patients in the PA (p<0.005) and 
WT (p<0.001) groups than in patients in the C group. Similarly, the systemic immune-inflammation index was found 
significantly higher in patients in the PA and WT (p<0.005) groups than in patients in the C group. The platelet-tolymphocyte ratio was significantly higher in patients in the PA group than in patients in the WT (p<0.05) and C groups 
(p<0.05).
Conclusion: In both WT and PA groups, the inflammatory status of the patients was found altered. Thus, inflammation 
and the immune system seem to have a role in the genesis of these benign salivary neoplasms whose etiopathogenesis 
is still debated.
AU  - IACONETTA, GIORGIO
AU  - Califano, Luigi
AU  - barone, simona
AU  - Bonavolontà, Paola
AU  - GALDIERO, MARIA ROSARIA
AU  - Dell'Aversana Orabona, Giovanni
AU  - Cristinziano, Leonardo
AU  - Abbate, Vincenzo
AU  - Modestino, Luca
DO  - 10.14744/ejmo.2022.29857
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 2
SN  - 2587-2400
SP  - 150
EP  - 155
DB  - TRDizin
UR  - http://search/yayin/detay/531307
ER  -