TY  - JOUR
TI  - Can Spesific Biomarkers Be Used to Enlighten the Major Mechanisms 
of Acute High Dose Diclofenac Sodium-Related Nephrotoxicity?
AB  - Aim: The aim of this study was to examine the basic mechanisms that play a role in the acute nephrotoxicity caused by diclofenac sodium.
Materials and Methods: Only water was given to the control group; however, the diclofenac sodium group was group intoxicated by giving 
water-soluble, 240 mg/kg, oral single dose diclofenac sodium. After 24 hours, all animals were sacrificed and histopathological analyzes 
were performed. The levels of spesific biomarkers [vascular endothelial growth factor (VEGF), nuclear factor-kappa B (NF-κB), matrix 
metalloproteinase-9 (MMP-9), metalloproteinase tissue inhibitor-1 (TIMP-1) and carcinoembryonic antigen (CEA)] that may be related to the 
nephrotoxicity mechanism were evaluated. 
Results: As a result of biochemical analysis, we found that VEGF, TIMP-1, NF-κB and CEA levels were significantly higher and MMP-9 levels 
were significantly lower in diclofenac sodium group compared to control group. Nephrotoxicity related histopathological changes were 
observed in the sections of diclofenac sodium group.
Conclusion: This study has shown that the biomarkers we evaluated in the diclofenac sodium-induced acute high-dose intoxication model we 
created can help us to identify the nephrotoxicity and to explain the nephrotoxicity mechanism with the three main steps (the hemodynamicrelated pathway, the inflammation-related pathway, and the oxidative stress-related pathway). With a simple version of this panel adapted to 
emergency departments, we may be able to diagnose diclofenac sodium-related nephrotoxicity.
AU  - AKGOL GUR, Sultan Tuna
AU  - kocak, abdullah osman
AU  - leylek, habip emrah
AU  - Akbaş, İlker
AU  - cokbankir, ozge
AU  - AYGORMEZ, Serpil
AU  - Dogruyol, Sinem
DO  - 10.4274/eajem.galenos.2021.45467
PY  - 2022
JO  - Eurasian Journal of Emergency Medicine
VL  - 21
IS  - 2
SN  - 2149-5807
SP  - 132
EP  - 137
DB  - TRDizin
UR  - http://search/yayin/detay/531580
ER  -