TY  - JOUR
TI  - The Effect of Rat Adipose-derived Stem Cells in Bone Tissue Regeneration
AB  - Stem cell approaches has been increasing in the conventional medicine. Th is study was planned to determinate the efficacy of
adipose-derived stem cells (ADSCs) on the bone fracture’s regeneration by histologically, morphologically and radiologically. Primarily
isolated cells were cultivated and identified for the obtaining of the third passage mesenchymal stem cells in the cell culture laboratory.
Th e right tibias (applicated ADSCs) were planned as experimental group and the left tibias were studied as control on the clinically
healthy 10 rats. Th e middle diaphysis of the right and left tibias was transversally cut by a thin saw and then fixed by intramedullary pin.
Before surgical closure of the incised area, 106 ADSCs were injected on an absorbent material, which covered the cut site of the right tibia,
in experimental group. At postoperative 45th day, cranio-caudal and lateral radiographs of the tibias pointed out that there was callus
formation in the caudal and lateral parts of the right tibia. After sacrification of the animals, preparations were made for histological
examinations. Th e results indicate that there were clear diff erences in the mitotic activity; and also, the experimental tibias were found to
be rich in blood vessel network. As a conclusion, it was found that ADSCs can have a positive potential effect on osteogenesis in
bone tissue.
AU  - ÇETİN, Melike
AU  - ÇERÇİ, Ece
AU  - OZGÜDEN AKKOÇ, CANSEL GÜZIN
AU  - canatan, uygur
AU  - SALCI, Hakan
AU  - İLHAN, Tuncay
AU  - ERDOST, Hatice
DO  - 10.9775/kvfd.2021.27069
PY  - 2022
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 28
IS  - 3
SN  - 1300-6045
SP  - 355
EP  - 362
DB  - TRDizin
UR  - http://search/yayin/detay/532207
ER  -