Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy
Yıl: 2021 Cilt: 6 Sayı: 2 Sayfa Aralığı: 88 - 91 Metin Dili: İngilizce DOI: 10.25000/acem.870894 İndeks Tarihi: 07-07-2022
Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy
Öz: Aim: Anti-tumor necrosis factor-alpha (TNF-α) drug treatments are widely used in many inflammatory diseases.
Neurological complications have rarely been reported in these treatments. Our aim in this study was to
investigate the neurological findings that occurred in our patients receiving this treatment.
Methods: A case-control study conducted in (institutional information was blinded) between September 2018-
September 2019. The study included 35 patients receiving tumor necrosis factor-alpha blocker drug, and 37
healthy control subjects with similar demographic characteristics. The disease activity scores of the patient
group and physical function scores of the patient and control groups were questioned. All patients underwent a
detailed physical and neurological examination. Afterward, peripheral nerves were evaluated
neurophysiologically. According to distribution Mann-Whitney U test or independent samples t-test was used
when comparing groups. The relationship between Short Form-36 and age or body mass index was determined
by using Spearman’s rank correlation coefficient.
Results: The results obtained in sensory and motor nerve conduction examinations were compared between
groups. Patients using anti-tumor necrosis factor-alpha had peripheral sensory neuropathy. Examination of
peripheral motor nerves was within normal limits.
Conclusions: Anti-tumor necrosis factor-alpha drugs have good effects in inflammatory diseases. These patients
should be carefully monitored for neurological findings.
Anahtar Kelime: Anti-tümör nekroz faktör-alfa ilaç tedavisi alan hastalarda periferik sinirlerindeğerlendirilmesi
Öz: Amaç: Anti-tümör nekroz faktör-alfa (TNF-α) ilaç tedavileri, birçok enflamatuar hastalıkta yaygın olarak
kullanılmaktadır. Bu tedavilerde nadiren nörolojik komplikasyonlar bildirilmiştir. Bu çalışmadaki amacımız, bu
tedaviyi alan hastalarımızda ortaya çıkan nörolojik bulguları araştırmaktı.
Yöntemler: Eylül 2018-Eylül 2019 arasında (kurumsal bilgi körlendi) yürütülen bir vaka kontrol çalışmasıdır.
Çalışmaya tümör nekroz faktör-alfa bloker ilaç alan 35 hasta ve benzer demografik özelliklere sahip 37 sağlıklı
kontrol deneği dahil edildi. Hasta grubunun hastalık aktivite skorları ile hasta ve kontrol grubunun fiziksel
fonksiyon skorları sorgulandı. Tüm hastalara detaylı fiziksel ve nörolojik muayene yapıldı. Daha sonra periferik
sinirler nörofizyolojik olarak değerlendirildi. Dağılıma göre gruplar karşılaştırılırken Mann-Whitney U testi
veya Independent samples t-testi kullanıldı. Kısa Form-36 ile yaş veya vücut kitle indeksi arasındaki ilişki,
Spearman'ın sıra korelasyon katsayısı kullanılarak belirlendi.
Bulgular: Duyusal ve motor sinir ileti incelemelerinde elde edilen sonuçlar gruplar arasında karşılaştırıldı. Antitümör nekroz faktör-alfa ilacı kullanan hastalarda periferik duyusal nöropati tespit edildi. Periferik motor
sinirlerin incelemesi normal sınırlardaydı.
Sonuç: Anti-tümör nekroz faktör-alfa ilaçları enflamatuar hastalıklarda oldukça etkilidir. Bu ilaçları kullanan
hastalar nörolojik bulgular açısından dikkatle izlenmelidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Ekinci B, Yaşar H, ARSLAN Y (2021). Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. , 88 - 91. 10.25000/acem.870894 |
| Chicago | Ekinci Bilge,Yaşar Hasan,ARSLAN Yusuf Kemal Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. (2021): 88 - 91. 10.25000/acem.870894 |
| MLA | Ekinci Bilge,Yaşar Hasan,ARSLAN Yusuf Kemal Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. , 2021, ss.88 - 91. 10.25000/acem.870894 |
| AMA | Ekinci B,Yaşar H,ARSLAN Y Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. . 2021; 88 - 91. 10.25000/acem.870894 |
| Vancouver | Ekinci B,Yaşar H,ARSLAN Y Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. . 2021; 88 - 91. 10.25000/acem.870894 |
| IEEE | Ekinci B,Yaşar H,ARSLAN Y "Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy." , ss.88 - 91, 2021. 10.25000/acem.870894 |
| ISNAD | Ekinci, Bilge vd. "Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy". (2021), 88-91. https://doi.org/10.25000/acem.870894 |
| APA | Ekinci B, Yaşar H, ARSLAN Y (2021). Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. Archives of Clinical and Experimental Medicine, 6(2), 88 - 91. 10.25000/acem.870894 |
| Chicago | Ekinci Bilge,Yaşar Hasan,ARSLAN Yusuf Kemal Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. Archives of Clinical and Experimental Medicine 6, no.2 (2021): 88 - 91. 10.25000/acem.870894 |
| MLA | Ekinci Bilge,Yaşar Hasan,ARSLAN Yusuf Kemal Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. Archives of Clinical and Experimental Medicine, vol.6, no.2, 2021, ss.88 - 91. 10.25000/acem.870894 |
| AMA | Ekinci B,Yaşar H,ARSLAN Y Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. Archives of Clinical and Experimental Medicine. 2021; 6(2): 88 - 91. 10.25000/acem.870894 |
| Vancouver | Ekinci B,Yaşar H,ARSLAN Y Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy. Archives of Clinical and Experimental Medicine. 2021; 6(2): 88 - 91. 10.25000/acem.870894 |
| IEEE | Ekinci B,Yaşar H,ARSLAN Y "Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy." Archives of Clinical and Experimental Medicine, 6, ss.88 - 91, 2021. 10.25000/acem.870894 |
| ISNAD | Ekinci, Bilge vd. "Evaluation of peripheral nerves in patients receiving anti-tumor necrosis factor-alpha drug therapy". Archives of Clinical and Experimental Medicine 6/2 (2021), 88-91. https://doi.org/10.25000/acem.870894 |
