TY  - JOUR
TI  - Evaluation of peripheral nerves in patients receiving anti-tumor 
necrosis factor-alpha drug therapy
AB  - Aim: Anti-tumor necrosis factor-alpha (TNF-α) drug treatments are widely used in many inflammatory diseases. 
Neurological complications have rarely been reported in these treatments. Our aim in this study was to 
investigate the neurological findings that occurred in our patients receiving this treatment.
Methods: A case-control study conducted in (institutional information was blinded) between September 2018-
September 2019. The study included 35 patients receiving tumor necrosis factor-alpha blocker drug, and 37 
healthy control subjects with similar demographic characteristics. The disease activity scores of the patient 
group and physical function scores of the patient and control groups were questioned. All patients underwent a 
detailed physical and neurological examination. Afterward, peripheral nerves were evaluated 
neurophysiologically. According to distribution Mann-Whitney U test or independent samples t-test was used 
when comparing groups. The relationship between Short Form-36 and age or body mass index was determined 
by using Spearman’s rank correlation coefficient.
Results: The results obtained in sensory and motor nerve conduction examinations were compared between 
groups. Patients using anti-tumor necrosis factor-alpha had peripheral sensory neuropathy. Examination of 
peripheral motor nerves was within normal limits.
Conclusions: Anti-tumor necrosis factor-alpha drugs have good effects in inflammatory diseases. These patients 
should be carefully monitored for neurological findings.
AU  - ARSLAN, Yusuf Kemal
AU  - Yaşar, Hasan
AU  - Ekinci, Bilge
DO  - 10.25000/acem.870894
PY  - 2021
JO  - Archives of Clinical and Experimental Medicine
VL  - 6
IS  - 2
SN  - 2564-6567
SP  - 88
EP  - 91
DB  - TRDizin
UR  - http://search/yayin/detay/532383
ER  -