Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi
Yıl: 2022 Cilt: 6 Sayı: 1 Sayfa Aralığı: 71 - 76 Metin Dili: Türkçe DOI: 10.46332/aemj.886928 İndeks Tarihi: 29-07-2022
Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi
Öz: Amaç: Küçük Hücreli akciğer kanseri (KHAK)kemoterapiye duyarlı ancak kötü prognozu olan bir akciğer kanseri türüdür. Bu çalışmamızda lenfosit/monosit oranının ile birlikte diğer klinik ve laboratuvar parametrelerinin prognostik önemini araştırmayı amaçladık.Araçlar ve Yöntem: Bu çalışmamızda retrospektif olarak Ocak 2014 ile Aralık 2019 tarihleri arasında KHAK tanısı almış ve yaygın evrede olan 146 hastanın tıbbi kayıtları incelendi. Kemoterapi öncesi alınan kan tetkiklerinden lenfosit/monosit oranı (LMO) hesaplandı.Bulgular: Çalışmaya alınan hastalarda medyan genel sağ kalım süresi 8.78 (aralık 1.07-54.80) ay, progresyonsuz sağ kalım süresi (PSK) 5.6 (1.07–44.03) ay olarak bulundu. Tüm hastaların kohort analizinde, LMO düşük grupta medyan PSK 4.5 ay, genel sağ kalım süresi (GSK) 7.5 ay olup, LMO yüksek grupta medyan PSK 6.5 ay, GSK 10.1 ay olarak saptandı. Tek değişkenli analiz ile incelendiğinde LMO yüksek olan hastaların düşük olan hastalara göre genel sağ kalım süreleri de daha uzundu (HR 0.591 %95 CI 0.42-0.83 p=0.003). Çok değişkenli analiz ile incelendiğinde ise LMO yüksekliği sağ kalım için iyi prognostik göstergelerden biri olma özelliğini devam ettiriyordu (HR: 0.54 %95 CI 0.38-0.77. p=0.001)Sonuç: Yüksek LMO, yaygın evre küçük hücreli akciğer kanseri hastalarında uzunPSK ve GSK’yı gösteren bağımsız bir prognostik parametre olabileceği kanıtlandı.
Anahtar Kelime: Prognostic Significance of the Lymphocyte/Monocyte Ratio in Patients with Extensive Stage Small Cell Lung Cancer
Öz: Purpose: Small cell lung cancer (SCLC) is a type of lung cancer that is sensitive to chemotherapy but has a poor prognosis. In this study, we aimed to investigate the prognostic significance of the lymphocyte / monocyte ratio and clinical and laboratory parameters.Materials and Methods: In this study, medical records of 146 patients who were diagnosed with SCLC between January 2014 and December 2019 and were in the extensive stage were analyzed retrospectively. The lymphocyte / monocyte ratio (LMO) was calculated from the blood tests taken before chemotherapy.Results: Median overall survival (OS) was 8.78 (range 1.07-54.80) months, progression-free survival (PFS) was 5.6 (1.07 - 44.03) months in the patients enrolled in the study. In the cohort analysis of all patients, the median PFS was 4.5 months, OS 7.5 months in the low group with LMO and 6.5 months, OS 10.1 months in the high group with LMO. When examined by univariate analysis, patients with high LMO also had longer OS than patients with low (HR 0.591 95% CI 0.42-0.83 p=0.003). When analyzed by multivariate analysis, LMOcontinued to be one of the good prognostic parameter for survival (HR: 0.54% 95 CI 0.38-0.77. p=0.001)Conclusion: It has been shown that high LMO can be an independent prognostic parameter showing long PFS and OS in patients with extensive stage small cell lung cancer.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | iriagac Y, Çavdar E, YOLCU A (2022). Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. , 71 - 76. 10.46332/aemj.886928 |
| Chicago | iriagac Yakup,Çavdar Eyyüp,YOLCU AHMET Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. (2022): 71 - 76. 10.46332/aemj.886928 |
| MLA | iriagac Yakup,Çavdar Eyyüp,YOLCU AHMET Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. , 2022, ss.71 - 76. 10.46332/aemj.886928 |
| AMA | iriagac Y,Çavdar E,YOLCU A Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. . 2022; 71 - 76. 10.46332/aemj.886928 |
| Vancouver | iriagac Y,Çavdar E,YOLCU A Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. . 2022; 71 - 76. 10.46332/aemj.886928 |
| IEEE | iriagac Y,Çavdar E,YOLCU A "Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi." , ss.71 - 76, 2022. 10.46332/aemj.886928 |
| ISNAD | iriagac, Yakup vd. "Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi". (2022), 71-76. https://doi.org/10.46332/aemj.886928 |
| APA | iriagac Y, Çavdar E, YOLCU A (2022). Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. Ahi Evran Medical Journal, 6(1), 71 - 76. 10.46332/aemj.886928 |
| Chicago | iriagac Yakup,Çavdar Eyyüp,YOLCU AHMET Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. Ahi Evran Medical Journal 6, no.1 (2022): 71 - 76. 10.46332/aemj.886928 |
| MLA | iriagac Yakup,Çavdar Eyyüp,YOLCU AHMET Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. Ahi Evran Medical Journal, vol.6, no.1, 2022, ss.71 - 76. 10.46332/aemj.886928 |
| AMA | iriagac Y,Çavdar E,YOLCU A Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. Ahi Evran Medical Journal. 2022; 6(1): 71 - 76. 10.46332/aemj.886928 |
| Vancouver | iriagac Y,Çavdar E,YOLCU A Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi. Ahi Evran Medical Journal. 2022; 6(1): 71 - 76. 10.46332/aemj.886928 |
| IEEE | iriagac Y,Çavdar E,YOLCU A "Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi." Ahi Evran Medical Journal, 6, ss.71 - 76, 2022. 10.46332/aemj.886928 |
| ISNAD | iriagac, Yakup vd. "Yaygın Evre Küçük Hücreli Akciğer Kanserinde Lenfosit/Monosit Oranının Prognostik Önemi". Ahi Evran Medical Journal 6/1 (2022), 71-76. https://doi.org/10.46332/aemj.886928 |
