TY  - JOUR
TI  - Frequency of glucose-6-phosphate dehydrogenase 
enzyme deficiency in newborns with prolonged jaundice
AB  - Objective: The aim of the study was to determine the frequency of glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency in preterm and term newborns with 
prolonged jaundice.
Material and Methods: A total of 670 preterm and term newborns who applied to 
Zeynep Kamil Training and Research Hospital Pediatric Health Polyclinic with neonatal 
jaundice between January 1, 2014, and April 1, 2018, were retrospectively screened 
and included in the study. Birth weight, sex, gestational week, postnatal age, gender, 
phototherapy, and need for exchange transfusion were recorded. Laboratory evaluations included blood group typing of mother and newborn, serum total and direct 
bilirubin levels, reticulocyte count, and erythrocyte G6PD level. SPSS 22.0 was used 
as an evaluation program.
Results: G6PD enzyme level was detected in 374 (55.8%) of the cases. Enzyme 
deficiency was detected in 12 (3.2%) cases. There was no statistically significant 
difference between the G6PD-deficient group and the G6PD-normal group in terms of 
all parameters except the total biluribin level. There was no case in whom exchange 
transfusion was performed with high bilirubin values. However, phototherapy was applied in 231 cases due to high bilirubin levels. It was determined that there was no 
need for phototherapy in all cases with G6PD levels.
Conclusion: G6PD enzyme deficiency should be investigated in patients with prolonged jaundice.
AU  - bozaykut, abdulkadir
AU  - taştanoğlu, hüseyin
AU  - Sezer Yamanel, Rabia Gönül
DO  - 10.14744/zkmj.2021.88709
PY  - 2022
JO  - Zeynep Kamil medical journal (Online)
VL  - 53
IS  - 2
SN  - 2757-8062
SP  - 75
EP  - 79
DB  - TRDizin
UR  - http://search/yayin/detay/532998
ER  -