Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities

Murat TÜRKYILMAZ, (Trakya Üniversitesi, Fen Fakültesi, Kimya Bölümü, Edirne, Türkiye)
Murat DÖNMEZ, (Trakya Üniversitesi, Fen Fakültesi, Kimya Bölümü, Edirne, Türkiye)
Murat ATEŞ (Tekirdağ Namık Kemal Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Tekirdağ, Türkiye)
Journal of sustainable construction materials and technologies (Online)
13 0
Yıl: 2022 Cilt: 7 Sayı: 2 Sayfa Aralığı: 53 - 61 Metin Dili: İngilizce DOI: 10.47481/jscmt.1117139 İndeks Tarihi: 29-07-2022

Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities

Öz:
In this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections to NHCs (2a–c). New complexes containing the symmetric N-heterocyclic carbene (NHC) ligands were synthesized using azolium salts in dimethyl formamide (DMF). After the NHC predecessor compounds reacted with Ag2O, Ag(I)-NHC complexes were synthesized in the following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionedium silver(I)bromide (3a), 7,9-di(acetamide)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-di-ondium silver(I)bromide (3b) and 7,9-di(methylacetate)-8,9-dihydro-1,3-dimethyl-1H-pu-rine-2,6(3H,7H)-diondiumsilver(I)bromide (3c). Both synthesized NHC predecessors (2a-c) and Ag(I)-NHC complexes (3a-c) were described by FTIR, 1H-NMR, 13C-NMR, liquid and solid-state conductivity values, TGA analysis, melting point analysis and XRD spectroscopy. In-vitro antibacterial activities of NHC-predecessors and Ag(I)-NHC complexes were tested against gram-positive bacteria (Staphylococcus Aureus and Bacillus Cereus), gram-negative bacteria (Escherichia Coli and Listeria Monocytogenes), and fungus (Candida Albicans) in Tryptic Soy Broth method. Ag(I)-NHC complexes showed higher antibacterial activity than pure NHC predecessors. The lowest microbial inhibition concentration (MIC) value of compound 3a was obtained as 11.56 μg/ml for Escherichia Coli and 11.52 μg/ml for Staphylococcus Aureus. All tested complexes displayed antimicrobial activity with different results.
Anahtar Kelime: Antimicrobial activity Candida Albicans SEM analysis. theophylline

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA türkyılmaz m, Dönmez M, Ates M (2022). Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. , 53 - 61. 10.47481/jscmt.1117139
Chicago türkyılmaz murat,Dönmez Murat,Ates Murat Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. (2022): 53 - 61. 10.47481/jscmt.1117139
MLA türkyılmaz murat,Dönmez Murat,Ates Murat Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. , 2022, ss.53 - 61. 10.47481/jscmt.1117139
AMA türkyılmaz m,Dönmez M,Ates M Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. . 2022; 53 - 61. 10.47481/jscmt.1117139
Vancouver türkyılmaz m,Dönmez M,Ates M Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. . 2022; 53 - 61. 10.47481/jscmt.1117139
IEEE türkyılmaz m,Dönmez M,Ates M "Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities." , ss.53 - 61, 2022. 10.47481/jscmt.1117139
ISNAD türkyılmaz, murat vd. "Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities". (2022), 53-61. https://doi.org/10.47481/jscmt.1117139
APA türkyılmaz m, Dönmez M, Ates M (2022). Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. Journal of sustainable construction materials and technologies (Online), 7(2), 53 - 61. 10.47481/jscmt.1117139
Chicago türkyılmaz murat,Dönmez Murat,Ates Murat Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. Journal of sustainable construction materials and technologies (Online) 7, no.2 (2022): 53 - 61. 10.47481/jscmt.1117139
MLA türkyılmaz murat,Dönmez Murat,Ates Murat Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. Journal of sustainable construction materials and technologies (Online), vol.7, no.2, 2022, ss.53 - 61. 10.47481/jscmt.1117139
AMA türkyılmaz m,Dönmez M,Ates M Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. Journal of sustainable construction materials and technologies (Online). 2022; 7(2): 53 - 61. 10.47481/jscmt.1117139
Vancouver türkyılmaz m,Dönmez M,Ates M Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities. Journal of sustainable construction materials and technologies (Online). 2022; 7(2): 53 - 61. 10.47481/jscmt.1117139
IEEE türkyılmaz m,Dönmez M,Ates M "Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities." Journal of sustainable construction materials and technologies (Online), 7, ss.53 - 61, 2022. 10.47481/jscmt.1117139
ISNAD türkyılmaz, murat vd. "Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities". Journal of sustainable construction materials and technologies (Online) 7/2 (2022), 53-61. https://doi.org/10.47481/jscmt.1117139
Sayfa Oluşturulma Tarihi
23-04-2024 23:57

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