TY  - JOUR
TI  - Cyclosporine Therapy as a Rescue Treatment in Steroid
Refractory Acute Severe Ulcerative Colitis: A Real Life Data
From a Tertiary Center
AB  - Background: Cyclosporine is a rescue treatment alternative to avoid colectomy in corticosteroid refractory acute severe ulcerative
colitis.
In this study, we aimed to evaluate the long-term efficacy and safety of cyclosporine therapy in acute severe ulcerative colitis
patients.
Methods: Acute severe ulcerative colitis (basal Lichtiger score > 10) patients who did not respond to 40 mg intravenous methylprednisolone
therapy after 3-5 days were included in the study. The presence of clinical response and remission was assessed at 1st week, 1st,
6th, and 12th month according to the Lichtiger index.
Results: In this study, 40 patients, whose steroid refractory acute severe ulcerative colitis and basal Lichtiger score > 10 points were
enrolled. The median disease duration was 49.3 months (2-204). All patients received cyclosporine for 132 ± 78 days (7-270). Clinical
response was obtained on seventh day in 82.5%. The clinical response rates of the first and sixth months were 72.5% and 62.5%,
respectively.
A total of 17/40 (42.5%) patients underwent colectomy within 1 year. In the patients who underwent colectomy, the basal
LS (14.2 ± 1.9 vs 12.3 ± 1.7) (P = .002) was higher and the basal hemoglobin value (11.8 ± 2.3 vs 10.1 ± 1.5) (P = .037) was lower than those
who did not undergo colectomy.
Conclusion: Our findings suggest that cyclosporine treatment may be successfully and safely used in steroid refractory acute severe
ulcerative colitis patients. Cyclosporine is a drug that has recently started to come up again with the introduction of new maintenance
treatments. Especially in patients who develop a loss of response to infliximab therapy, or where infliximab therapy is contraindicated,
or who have azathioprine intolerance, or are unresponsive.
AU  - Akyuz, Filiz
AU  - Ormeci, Asli
AU  - Beşışık, Fatih
AU  - Demir, Kadir
AU  - Mutluay Soyer, Ozlem
AU  - Baran, Bulent
AU  - Karaca, Cetin
AU  - Pınarbaşı Şimşek, Binnur
AU  - gokturk, suut
AU  - Çavuş, Bilger
AU  - Kaymakoglu, Sabahattin
AU  - İliaz, Raim
AU  - Evirgen, Sami
DO  - 10.5152/tjg.2022.21093
PY  - 2022
JO  - Turkish Journal of Gastroenterology
VL  - 33
IS  - 6
SN  - 1300-4948
SP  - 463
EP  - 469
DB  - TRDizin
UR  - http://search/yayin/detay/533274
ER  -