TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population
Yıl: 2022 Cilt: 33 Sayı: 6 Sayfa Aralığı: 485 - 490 Metin Dili: İngilizce DOI: 10.5152/tjg.2022.21189 İndeks Tarihi: 10-07-2022
TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population
Öz: Background: We aimed to evaluate the association between the TP53 Arg72Pro gene polymorphism and risk of colorectal cancer in an
Azerbaijani population.
Methods: A total of 141 patients with colorectal cancer and 150 gender- and age-matched controls were involved in the study. The
genotypes of the TP53 gene Arg72Pro polymorphism were detected by polymerase chain reaction-based restriction fragment length
polymorphism analysis.
Results: We found that the heterozygous genotypes Arg/Pro (odds ratio, 1.128; 95% CI, 0.657-1.937) and mutant Pro/Pro (odds ratio,
1.274; 95% CI, 0.648-2.504) were more frequent in colorectal cancer patients compared to healthy controls. The frequency of the
mutant Pro allele (odds ratio, 1.122; 95% CI, 0.809-1.554) was revealed in 47.5% of colorectal cancer patients and in 44.7% of healthy
controls. There was no association observed between TP53 Arg72Pro polymorphism and risk of colorectal cancer in an Azerbaijani
population (P > .05).
Conclusion: Our findings indicate a lack of relationship between TP53 Arg72Pro polymorphism and risk of colorectal cancer. Furthermore,
we have found no statistical differences in the frequency of genotype and allele by sex, age, histological grade, tumor stage, smoking
status, and alcohol consumption in this study.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Yagublu V, Bayramov B, YÜCE M, Aslanov H (2022). TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. , 485 - 490. 10.5152/tjg.2022.21189 |
| Chicago | Yagublu Vugar,Bayramov Bayram,YÜCE MELEK,Aslanov Hazi TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. (2022): 485 - 490. 10.5152/tjg.2022.21189 |
| MLA | Yagublu Vugar,Bayramov Bayram,YÜCE MELEK,Aslanov Hazi TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. , 2022, ss.485 - 490. 10.5152/tjg.2022.21189 |
| AMA | Yagublu V,Bayramov B,YÜCE M,Aslanov H TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. . 2022; 485 - 490. 10.5152/tjg.2022.21189 |
| Vancouver | Yagublu V,Bayramov B,YÜCE M,Aslanov H TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. . 2022; 485 - 490. 10.5152/tjg.2022.21189 |
| IEEE | Yagublu V,Bayramov B,YÜCE M,Aslanov H "TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population." , ss.485 - 490, 2022. 10.5152/tjg.2022.21189 |
| ISNAD | Yagublu, Vugar vd. "TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population". (2022), 485-490. https://doi.org/10.5152/tjg.2022.21189 |
| APA | Yagublu V, Bayramov B, YÜCE M, Aslanov H (2022). TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. Turkish Journal of Gastroenterology, 33(6), 485 - 490. 10.5152/tjg.2022.21189 |
| Chicago | Yagublu Vugar,Bayramov Bayram,YÜCE MELEK,Aslanov Hazi TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. Turkish Journal of Gastroenterology 33, no.6 (2022): 485 - 490. 10.5152/tjg.2022.21189 |
| MLA | Yagublu Vugar,Bayramov Bayram,YÜCE MELEK,Aslanov Hazi TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. Turkish Journal of Gastroenterology, vol.33, no.6, 2022, ss.485 - 490. 10.5152/tjg.2022.21189 |
| AMA | Yagublu V,Bayramov B,YÜCE M,Aslanov H TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. Turkish Journal of Gastroenterology. 2022; 33(6): 485 - 490. 10.5152/tjg.2022.21189 |
| Vancouver | Yagublu V,Bayramov B,YÜCE M,Aslanov H TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population. Turkish Journal of Gastroenterology. 2022; 33(6): 485 - 490. 10.5152/tjg.2022.21189 |
| IEEE | Yagublu V,Bayramov B,YÜCE M,Aslanov H "TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population." Turkish Journal of Gastroenterology, 33, ss.485 - 490, 2022. 10.5152/tjg.2022.21189 |
| ISNAD | Yagublu, Vugar vd. "TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population". Turkish Journal of Gastroenterology 33/6 (2022), 485-490. https://doi.org/10.5152/tjg.2022.21189 |
