Purpose: In pediatric burns, prolonged treatment processes can be psychosocially challenging for mothers who take the role of caregivers. The aim of this study was to investigate the factors affecting family burden in pediatric burn injuries. Methods: Thirty-two (18F/14M) children with burn injuries and their mothers were included in this study. The demographic data of the children and mothers and the data regarding burn injury were recorded. The burden of the child on family, anxiety levels of the mothers, hypertrophic scar quality and the range of motion (ROM) at the joints were evaluated with the Family Impact Scale (FIS), State Trait Anxiety Scale, Patient and Observer Scar Assessment Scale and a goniometer, respectively. Results: According to multiple linear regression analysis results, mothers ‘anxiety level, quality of hypertrophic scar, presence of pressure garment, time since injury, total burn surface area (TBSA), limitation in any of the joint/upper limb joint ROMs and number of operations were found to be significant determinants for FIS (p˂0.05). Conclusion: The mother's high anxiety level, poor hypertrophic scar quality, the use of compression garments in the treatment, presence of limitation in the joints and increase in the time since injury, number of surgeries, and the TBSA increase the burden of the child on family. In burn treatment practices, it is recommended to choose approaches that will reduce the burden of the burn history on the family by evaluating the child and family as a holistic approach.