TY  - JOUR
TI  - A real-life analysis of patients with rheumatologic
diseases on biological treatments: Data from TURKBIO
Registry
AB  - Objective: TURKBIO registry, established in 2011, is the first nationwide biological database in Turkey.
This study aimed to provide an overview of TURKBIO data collected by June 2018.
Methods: The registry included adult patients with rheumatoid arthritis (RA), ankylosing spondylitis
(AS), nonradiographic axial spondyloarthritis (nr-AxSpA), and psoriatic arthritis (PsA). Demographic and
clinical features, disease activity markers, and other follow-up parameters, current and previous treatments,
and adverse events were registered electronically at each visit using open-source software. The
registration of patient-reported outcome measures was carried out electronically by the patients using
touch screens.
Results: TURKBIO registry included a total of 41,145 treatment series with biologicals. There were 2,588
patients with axSpA (2,459 AS and 129 nr-axSpA), 2,036 with RA, and 428 with PsA. The total number
of patients, including those with other diagnoses, was 5,718. In the follow-up period, the number of
patients and also visits steadily increased by years. The yearly mean number of visits per patient was
found to be 2.3. Significant improvements in disease activity and health assessment parameters were
observed following the biological treatments. Biologics were often given in combination with a conventional
synthetic disease-modifying antirheumatic drug in patients with RA. Infections were the
most commonly seen adverse events, followed by allergic reactions. Tuberculosis was observed in 12
patients, malignancy in 18, and treatment-related mortality in 31.
Conclusion: TURKBIO provided a valuable real-life experience with the use of biologics in rheumatic
diseases in Turkey.
AU  - can, gercek
AU  - Onen, Fatos
AU  - Solmaz, Dilek
AU  - PEHLIVAN, YAVUZ
AU  - Bes, Cemal
AU  - Yilmaz, Sema
AU  - Birlik, Merih
AU  - Çapar, Sedat
AU  - ŞENEL, SONER
AU  - Koca, Suleyman Serdar
AU  - öztürk, mehmet akif
AU  - Soysal Gündüz, Özgül
AU  - Cefle, Ayse
AU  - Akar, Servet
AU  - Sari, Ismail
AU  - Yazici, Ayten
AU  - TUFAN, ABDURRAHMAN
AU  - HAZNEDAROGLU, SEMINUR
AU  - Yildirim-Cetin, Gozde
AU  - Yolbas, Servet
AU  - Goker, Berna
AU  - Dalkılıç, Ediz
AU  - Akkoç, Nurullah
AU  - Erten, Şükran
AU  - Inanc, Nevsun
AU  - Direskeneli, Haner
AU  - Krogh, Niels Steen
AU  - Yavuz, Sule
AU  - Yıldız, Fatih
AU  - Yilmaz, Neslihan
DO  - 10.5152/eurjrheum.2022.21060
PY  - 2022
JO  - European Journal of Rheumatology
VL  - 9
IS  - 2
SN  - 2147-9720
SP  - 82
EP  - 87
DB  - TRDizin
UR  - http://search/yayin/detay/533376
ER  -