TY  - JOUR
TI  - Standart Prophylactic Granulocyte Colony Stimulating Factor Usage as a Part of Autologous Stem Cell Transplantati̇ on Procedure
AB  - Introduction: One of the major causes of morbidity and mortality of autologous hematopoietic stem cell transplantation (ASCT) is infections during prolonged neutropenia. In this study, we aimed to investigate the effect of prophylactic G-CSF use in ASCT patient on the frequency of infection, duration of neutrophil engraftment and neutropenia, length of hospital stay and transplant-related morbidity and mortality.
Methods: G-CSF has been routinely used after autologous stem cell transplantation in our unit for 3 years since February 2014. In this study, three years before and after the application consecutive auto-HSCT data were collected retrospectively. In addition to routine antimicrobial prophylaxis, In the group receiving G-CSF, 5mcg/kg/day G-CSF sc was started from fifth day and application was continued until neutrophil engraftment.
Results: A total of 226 patients (129 males, 97 females) were included in the study. In patients receiving prophylactic G-CSF, neutrophil engraftment was earlier [13 (9-23) and 12 (10-22) days], and the duration of neutropenia [11 (5-23) and 8 (5-19) days] was shorter (p <0.001). In the ASCT series prophylactic use of G-CSF showed that reduced the duration of neutropenia and decreased in neutropenic fever frequency.
Discussion and Conclusion: Transplant-related mortality (TRM) and infection-related mortality analyzes were not very significant due to the low level of event (p> 0.05)
AU  - GUZEL TUNCCAN, OZLEM
AU  - Yağcı, Münci
AU  - yegin, zeynep arzu
AU  - Can, Ferda
AU  - OZKURT, ZÜBEYDE NUR
AU  - AYDIN KAYNAR, LALE
DO  - 10.5505/aot.2022.47113
PY  - 2022
JO  - ACTA ONCOLOGICA TURCICA
VL  - 55
IS  - 1
SN  - 0304-596X
SP  - 52
EP  - 57
DB  - TRDizin
UR  - http://search/yayin/detay/533431
ER  -