TY  - JOUR
TI  - Does Orlistat Affect Levothyroxine Bioavailability?
AB  - Objectives: Orlistat is used in the treatment of obesity while hypothyroidism is treated with levothyroxine. In this study, the effect of orlistat treatment on thyroid stimulating hormone (TSH) was investigated.
Methods: The files of the patients who were followed up with the diagnosis of obesity and hypothyroidism were evaluated retrospectively. Patients with a body mass index (BMI) > 40 and receiving levothyroxine replacement therapy were included in the study. Group 1 consisted of 37 patients who received orlistat and levothyroxine while group 2 consisted of patients who received levothyroxine without orlistat. BMI and TSH values of patients were compared at baseline and at third month.
Results: Despite group 1 having mild increase in TSH at third month compared to baseline, no statistically significant difference was observed (p:0.328). No differences were observed between TSH values of group 2 at baseline and third month (p: 0.380). When BMI of group 1 were compared at baseline and third month, it was found to be statistically lower (p<0.01). In group 2, BMI were significantly lower when baseline values were compared with third month (p<0.01).
Conclusion: It would be appropriate to closely monitor thyroid function tests in patients on levothyroxine following initiation of orlistat treatment.
AU  - Aydın, Bünyamin
DO  - 10.14744/ejmi.2022.40513
PY  - 2022
JO  - Eurasian Journal of Medical Investigation
VL  - 6
IS  - 1
SN  - 2602-3164
SP  - 22
EP  - 27
DB  - TRDizin
UR  - http://search/yayin/detay/533523
ER  -