Yıl: 2022 Cilt: 56 Sayı: 1 Sayfa Aralığı: 21 - 25 Metin Dili: İngilizce DOI: 10.4274/turkderm.galenos.2022.89577 İndeks Tarihi: 18-07-2022
Acitretin
Öz: Acitretin is a synthetic retinoid and an active metabolite of etretinate. It shows its action in psoriasis treatment by suppressing proliferation
and enhancing the differentiation of keratinocytes. It differs from other systemic anti-psoriatic agents in that it is not immunosuppressive or
cytotoxic. It is used as a monotherapy or in combination with phototherapy in various clinical forms of psoriasis. Due to its teratogenicity, its
use in women of reproductive age is not recommended unless there is no alternative. Studies of this drug show that acitretin monotherapy is
less effective in plaque psoriasis than other conventional systemic therapies but is superior to them in generalized, palmoplantar, pustular, and
hyperkeratotic variants.
Anahtar Kelime: Asitretin
Öz: Asitretin etretinatın aktif metaboliti olan sentetik bir retinoiddir. Psoriasis tedavisinde keratinositlerin proliferasyonunu baskılayıp,
diferansiyasyonunu artırarak etki gösterir. Diğer sistemik antipsoriatik ajanlardan farkı immünosüpresif ve sitotoksik olmamasıdır. Psoriasisin
farklı klinik formlarında monoterapi ya da fototerapi ile birlikte kombine olarak kullanılmaktadır. Teratojenitesi nedeniyle alternatifi olduğu
sürece doğurganlık çağındaki kadınlarda kullanılması önerilmez. İlaçla ilgili çalışmalar asitretin monoterapisinin plak tip psoriasiste diğer
geleneksel sistemik tedavilerden daha az etkili olduğunu, jeneralize, palmoplanter püstüler ve hiperkeratotik varyantlarda diğer geleneksel
sistemik tedavilere göre daha üstün olduğunu göstermektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KUNDAKCI N (2022). Acitretin. , 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| Chicago | KUNDAKCI NİHAL Acitretin. (2022): 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| MLA | KUNDAKCI NİHAL Acitretin. , 2022, ss.21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| AMA | KUNDAKCI N Acitretin. . 2022; 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| Vancouver | KUNDAKCI N Acitretin. . 2022; 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| IEEE | KUNDAKCI N "Acitretin." , ss.21 - 25, 2022. 10.4274/turkderm.galenos.2022.89577 |
| ISNAD | KUNDAKCI, NİHAL. "Acitretin". (2022), 21-25. https://doi.org/10.4274/turkderm.galenos.2022.89577 |
| APA | KUNDAKCI N (2022). Acitretin. Türkderm Türk deri hastalıkları ve frengi arşivi, 56(1), 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| Chicago | KUNDAKCI NİHAL Acitretin. Türkderm Türk deri hastalıkları ve frengi arşivi 56, no.1 (2022): 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| MLA | KUNDAKCI NİHAL Acitretin. Türkderm Türk deri hastalıkları ve frengi arşivi, vol.56, no.1, 2022, ss.21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| AMA | KUNDAKCI N Acitretin. Türkderm Türk deri hastalıkları ve frengi arşivi. 2022; 56(1): 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| Vancouver | KUNDAKCI N Acitretin. Türkderm Türk deri hastalıkları ve frengi arşivi. 2022; 56(1): 21 - 25. 10.4274/turkderm.galenos.2022.89577 |
| IEEE | KUNDAKCI N "Acitretin." Türkderm Türk deri hastalıkları ve frengi arşivi, 56, ss.21 - 25, 2022. 10.4274/turkderm.galenos.2022.89577 |
| ISNAD | KUNDAKCI, NİHAL. "Acitretin". Türkderm Türk deri hastalıkları ve frengi arşivi 56/1 (2022), 21-25. https://doi.org/10.4274/turkderm.galenos.2022.89577 |
