TY  - JOUR
TI  - Value of FDG PET/CT in Predicting Pathologic Complete
Response After Neoadjuvant Chemotherapy in Locally
Advanced Breast Cancer
AB  - Objectives: To investigate the importance of FDG PET/CT in predicting pathologic complete response (pCR) in primary
breast lesions and axillary lymph nodes of patients with local, advanced breast cancer who were given neoadjuvant
chemotherapy (NAC).
Methods: One hundred twenty-one patients who had FDG PET/CT and underwent surgery due to local, advanced
breast cancer before and after NAC were involved in the study. SUVmax and SULpeak values before and after NAC were
evaluated using FDG PET/CT and post-surgical responses were re-evaluated.
Results: Our study included 121 patients in total and 34 patients (28.1%) had a complete response in the breast, and
53 patients (43.8%) had a complete response in axillary lymph nodes. PostSUVmax and PostSULpeak values ≤1.15 and
the activity presenting the pCR were controlled and the sensitivity and specificity were found as 61.8% and 61.8%, and
73.3% and 77.0%, respectively, for the breast (p<0.001 and p<0.001). The reduction rate (RR) of SUVmax >88% and the
SULpeak (RR) >81% values and the activity presenting the pCR were controlled and the sensitivity and specificity were
found as 80.0% and 81.8%, and 80.0% and 60.7%, respectively, for the breast (p<0.001 and p<0.001).
Conclusion: The decrease of SUVmax and SULpeak values detected between PET/CT studies before and after NAC
were well correlated with the pathologic response. FDG- PET/CT has high sensitivity and specificity in the evaluation of
treatment response rates in breast lesions of patients with breast cancer receiving NAC.
AU  - Abamor, Evrim
AU  - Kucukoz Uzun, Aysun
AU  - Tataroglu Ozyukseler, Deniz
AU  - Odabas, Hatice
AU  - ayhan, murat
AU  - Köstek, Osman
AU  - çoban kökten, şermin
AU  - YILDIRIM, MAHMUT EMRE
AU  - turan, nedim
DO  - 10.14744/ejmi.2022.43076
PY  - 2022
JO  - Eurasian Journal of Medical Investigation
VL  - 6
IS  - 2
SN  - 2602-3164
SP  - 165
EP  - 175
DB  - TRDizin
UR  - http://search/yayin/detay/534076
ER  -