Relationship between serum cadherin 6 and 11 levels
and severe and early-onset preeclampsia: A pilot
study

Soyer çalışkan, Canan; YURTCU, NAZAN; AVCI, BAHATTIN; GÜVEY, HURİ; hatirnaz, safak; çelik, samettin; Tinelli, Andrea

doi:10.4274/tjod.galenos.2022.25307

Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study

Huri GÜVEY, (Özel Parkhayat Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Kütahya, Türkiye)

Canan SOYER ÇALIŞKAN, (Samsun Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Samsun, Türkiye)

Samettin ÇELIK, (Samsun Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Samsun, Türkiye)

Nazan YURTÇU, (Sivas Cumhuriyet Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Sivas, Türkiye)

Şafak HATIRNAZ, (Medical Park Hastanesi, Tüp Bebek Ünitesi, Samsun, Türkiye)

Bahattin AVCI, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Ana Bilim Dalı, Samsun, Türkiye)

Andrea TİNELLİ (Verris delli Ponti Hospital, Clinic of Obstetrics and Gynecology, Scorrano, Lecce, Italy)

Turkish Journal of Obstetrics and Gynecology

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Yıl: 2022 Cilt: 19 Sayı: 2 Sayfa Aralığı: 104 - 110 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2022.25307 İndeks Tarihi: 18-07-2022

Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study

Öz:

Objective: Preeclampsia is a highly morbid disease of placental origin, life-threatening condition for both a pregnant woman and her fetus. Cadherin 6 and 11 are adhesion molecules that play an important role in trophoblastic development and placentation. In our study, we investigated the change in serum cadherin 6 and 11 levels in pregnant women with preeclampsia. Materials and Methods: Pregnant women with preeclampsia were selected and compared with healthy women (as a control group) for a one-year study. The serum alanine aminotransferase, aspartate aminotransferase, and cadherin levels 6 and 11 of participants were analyzed and compared. Results: A total of 189 pregnant women were subdivided into 2 groups as preeclamptic (n=94) and women with healthy pregnancy (n=95). The cadherin 6 and cadherin 11 levels of the preeclamptic patients were significantly higher than those in the control group (p=0.001), and they were found to be significantly higher mainly in patients with early-onset and severe preeclampsia group (p=0.001). The cut-off cadherin 6 and 11 values for severe preeclampsia were found as 98.174 ng/mL and 1.92 ng/mL; with sensitivity of 88.3% and 84% respectively (p=0.001). Conclusion: The data analysis showed elevated serum cadherin 6 and 11 levels associated with the severity and early onset of pre-eclampsia. Serum cadherin 6 and 11 levels can be a candidate marker for the prediction of preeclampsia

Anahtar Kelime:

Erken başlangıçlı ve ağır preeklampsi ile serum kaderin 6 ve 11 seviyeleri arasındaki ilişki: Bir pilot çalışma

Öz:

Amaç: Preeklampsi, plasenta kaynaklı oldukça morbid bir hastalık olup, hem gebe hem de fetüs için hayatı tehdit edici bir durumdur. Kaderin 6 ve 11, plasenta oluşumu ve trofoblastik gelişimde önemli bir rol oynayan adezyon molekülleridir. Çalışmamızda, preeklampsi olan gebe kadınlarda serum kaderin 6 ve 11 seviyelerindeki değişimleri incelemeyi amaçladık. Gereç ve Yöntemler: Bir yıllık bir çalışma çerçevesinde preeklampsi olan gebeler seçildi ve kontrol grubu olarak sağlıklı gebelerle karşılaştırıldı. Katılımcıların serum alaninaminotransferaz, aspartate aminotransferaz, kaderin 6 ve 11 seviyeleri analiz edildi ve karşılaştırıldı. Bulgular: Toplam 189 gebe, preeklamptik (n=94) ve sağlıklı gebeliği olan (n=95) olmak üzere iki gruba bölünmüştür. Preeklamptik hastaların kaderin 6 ve kaderin 11 düzeyleri kontrol grubuna göre anlamlı olarak yüksekti (p=0,001) ve özellikle erken başlangıçlı ve şiddetli preeklampsili hastalarda anlamlı olarak yüksek bulundu (p=0,001). Şiddetli preeklampsi için cut-off kaderin 6 ve 11 değerleri sırasıyla %88,3 ve %84 duyarlılıkla, 174 ng/mL ve 1,92 ng/ mL olarak bulundu (p=0,001). Sonuç: Verilerin analizi, yüksek serum kaderin 6 ve 11 seviyelerinin preeklampsinin şiddeti ve erken başlangıcı ile ilişkili olduğunu gösterdi. Serum kaderin 6 ve 11 seviyeleri, preeklampsinin öngörülmesi için aday birer belirteç olabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜVEY H, Soyer çalışkan C, çelik s, YURTCU N, hatirnaz s, AVCI B, Tinelli A (2022). Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. , 104 - 110. 10.4274/tjod.galenos.2022.25307
Chicago	GÜVEY HURİ,Soyer çalışkan Canan,çelik samettin,YURTCU NAZAN,hatirnaz safak,AVCI BAHATTIN,Tinelli Andrea Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. (2022): 104 - 110. 10.4274/tjod.galenos.2022.25307
MLA	GÜVEY HURİ,Soyer çalışkan Canan,çelik samettin,YURTCU NAZAN,hatirnaz safak,AVCI BAHATTIN,Tinelli Andrea Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. , 2022, ss.104 - 110. 10.4274/tjod.galenos.2022.25307
AMA	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. . 2022; 104 - 110. 10.4274/tjod.galenos.2022.25307
Vancouver	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. . 2022; 104 - 110. 10.4274/tjod.galenos.2022.25307
IEEE	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A "Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study." , ss.104 - 110, 2022. 10.4274/tjod.galenos.2022.25307
ISNAD	GÜVEY, HURİ vd. "Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study". (2022), 104-110. https://doi.org/10.4274/tjod.galenos.2022.25307

APA	GÜVEY H, Soyer çalışkan C, çelik s, YURTCU N, hatirnaz s, AVCI B, Tinelli A (2022). Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turkish Journal of Obstetrics and Gynecology, 19(2), 104 - 110. 10.4274/tjod.galenos.2022.25307
Chicago	GÜVEY HURİ,Soyer çalışkan Canan,çelik samettin,YURTCU NAZAN,hatirnaz safak,AVCI BAHATTIN,Tinelli Andrea Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turkish Journal of Obstetrics and Gynecology 19, no.2 (2022): 104 - 110. 10.4274/tjod.galenos.2022.25307
MLA	GÜVEY HURİ,Soyer çalışkan Canan,çelik samettin,YURTCU NAZAN,hatirnaz safak,AVCI BAHATTIN,Tinelli Andrea Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turkish Journal of Obstetrics and Gynecology, vol.19, no.2, 2022, ss.104 - 110. 10.4274/tjod.galenos.2022.25307
AMA	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turkish Journal of Obstetrics and Gynecology. 2022; 19(2): 104 - 110. 10.4274/tjod.galenos.2022.25307
Vancouver	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. Turkish Journal of Obstetrics and Gynecology. 2022; 19(2): 104 - 110. 10.4274/tjod.galenos.2022.25307
IEEE	GÜVEY H,Soyer çalışkan C,çelik s,YURTCU N,hatirnaz s,AVCI B,Tinelli A "Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study." Turkish Journal of Obstetrics and Gynecology, 19, ss.104 - 110, 2022. 10.4274/tjod.galenos.2022.25307
ISNAD	GÜVEY, HURİ vd. "Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study". Turkish Journal of Obstetrics and Gynecology 19/2 (2022), 104-110. https://doi.org/10.4274/tjod.galenos.2022.25307