TY  - JOUR
TI  - Clinicopathological Features of Gastroenteropancreatic
Neuroendocrine Tumors: A Retrospective Evaluation of
149 Cases
AB  - Objectives: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are heterogeneous tumor groups, and they are
rarely seen. Our study aims to analyze the clinicopathologic, demographic, and survival features of patients with GEP-NET.
Methods: The data of 149 patients was collected retrospectively. Clinicopathologic, demographic, and survival features
of patients with GEP-NET were investigated. Survival analysis was performed by using the Kaplan–Meier method
and compared with the log-rank test. Univariate and multivariate analyses were performed to determine independent
prognostic predictors of overall survival (OS).
Results: Of 149 patients with GEP-NET, 65 patients (43.6%) were female and 84 patients (56.4%) were male. The most
common, primary site of GEP-NET was stomach (40.3%). It was followed by pancreas (17.4%), small bowel/appendix
(16.8%), colorectal (14%), and unknown primary (11.5%), respectively. The 3- and 5-year OS rate for the entire cohort
were 69% and 60%, respectively. Median OS was not calculated, but the mean OS was 66.2 months. The factors significantly
affecting the OS rate were age, grade, presence of metastasis at diagnosis, tumor diameter, and Ki-67 proliferation
index in the univariate analysis. However, age was only meaningful in the multivariate analysis.
Conclusion: Patients with GEP-NET under 50 age who have smaller tumor diameter, lower tumor grade, Ki-67 proliferation
index, and absence of metastasis at the diagnosis have more prolonged survival.
AU  - Olgun, Polat
AU  - KÖŞECİ, Tolga
AU  - Seyyar, Mustafa
AU  - ata, serdar
AU  - cil, timucin
AU  - Bayram, Ertuğrul
AU  - TAS, Zeynel Abidin
AU  - DUMAN, Berna
DO  - 10.14744/ejmi.2022.21011
PY  - 2022
JO  - Eurasian Journal of Medical Investigation
VL  - 6
IS  - 2
SN  - 2602-3164
SP  - 222
EP  - 226
DB  - TRDizin
UR  - http://search/yayin/detay/534116
ER  -