Are Clinical Predictors of Oral Malignancy
Risk Changing? A Sample Study

KARACA, Betül; AYKUTLU, Umut; BOYACIOĞLU, Hayal; gürhan, ceyda; GÜNERİ, Pelin; ÖZER, Nezaket Ezgi

doi:10.4274/meandros.galenos.2021.16046

Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study

Nezaket Ezgi Özer, (Ege Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Anabilim Dalı, İzmir, Türkiye)

Betül Karaca, (Ege Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Anabilim Dalı, İzmir, Türkiye)

Ceyda Gürhan, (Ege Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Anabilim Dalı, İzmir, Türkiye)

Hayal Boyacıoğlu, (Ege Üniversitesi Fen Fakültesi, İstatistik Bölümü, İzmir, Türkiye)

Umut Aykutlu, (Ege Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, İzmir, Türkiye)

Pelin Güneri (Ege Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi Anabilim Dalı, İzmir, Türkiye)

Meandros Medical And Dental Journal

2 0

Yıl: 2022 Cilt: 23 Sayı: 2 Sayfa Aralığı: 175 - 181 Metin Dili: İngilizce DOI: 10.4274/meandros.galenos.2021.16046 İndeks Tarihi: 18-07-2022

Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study

Öz:

Objective: Our study assesss the clinical features of oral lesions that require histological examination and patient-reported symptoms to estimate the risk of malignancy and to determine the presence of any altered features. Materials and Methods: Demographic characteristics of 70 patients and clinical features of lesions were analyzed using chi-square test, Fisher’s Exact test of Independence and discriminant function analysis. Results: Margins, lymphadenopathy, patient’s self-awareness of the lesion associated with mass effect, surface texture, colour, ulceration, loss of function and pain were significant parameters indicating the risk of malignancy (p<0.05). Analyses of the parameters related to the high risk of malignancy have led to a statistical model for clinical differentiation of benign lesions from malignancies with an accuracy of 91.4% (p=0.016). The statistical model demonstrated that the most important discriminative features were margins, surface texture, patient’s self-awareness, lymphadenopathy, loss of function, ulceration, colour, and pain, respectively. Conclusion: In our study, age, gender, duration and localization did not anticipate the nature of the lesion. Our statistical model showed that irregular/indistinct margins and surface textures and the presence of lymphadenopathy have a higher risk of malignancy.

Anahtar Kelime:

Ağız Kanserinin Klinik Belirteçleri Değişiyor mu? Bir Örneklem Çalışması

Öz:

Amaç: Çalışmanın amacı histopatolojik inceleme gerektiren oral lezyonların klinik özellikleri ve hastaların sübjektif semptomları değerlendirilerek, malignite riski ile ilişkili parametrelerin ve farklılık sergileyen klinik özelliklerin belirlenmesidir. Gereç ve Yöntemler: Yetmiş hastaya ait demografik veriler, lezyonların klinik özellikleri ve hastaların sübjektif semptomları ki-kare testi, Fisher bağımsızlık ve diskriminant analizi ile değerlendirildi. Bulgular: Lezyonun sınırları, rengi, lenfadenopati varlığı, lezyon farkındalığı, yüzey özellikleri, ülserasyon, fonksiyon kaybı ve ağrı malignite riski açısından önemli parametreler olarak belirlendi (p<0,05). Verilerin analizi sonrası, lezyonları klinik açıdan benign ve malign olarak %91,4 doğrulukla ayırt edebilen istatistiksel bir model geliştirildi (p=0,016). Değişkenlerin diskriminant özellikleri incelendiğinde sırasıyla, lezyon sınırları, yüzey özellikleri, hastanın lezyon farkındalığı, lenfadenopati, fonksiyon kaybı, ülserasyon, lezyon rengi ve ağrı en önemli parametreler olarak saptandı. Sonuç: Örneklem grubumuzda yaş, cinsiyet, lezyonun süresi ve lokalizasyonu gibi özellikler malignite riski ile ilişkili bulunmadı. Geliştirilen istatistiksel modele göre, klinik olarak sınırları düzensiz/belirsiz, yüzeyi düzensiz/mikst lezyonların ve lenfadenopati varlığının malignite açısından daha yüksek risk taşıdığı belirlendi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZER N, KARACA B, gürhan c, BOYACIOĞLU H, AYKUTLU U, GÜNERİ P (2022). Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. , 175 - 181. 10.4274/meandros.galenos.2021.16046
Chicago	ÖZER Nezaket Ezgi,KARACA Betül,gürhan ceyda,BOYACIOĞLU Hayal,AYKUTLU Umut,GÜNERİ Pelin Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. (2022): 175 - 181. 10.4274/meandros.galenos.2021.16046
MLA	ÖZER Nezaket Ezgi,KARACA Betül,gürhan ceyda,BOYACIOĞLU Hayal,AYKUTLU Umut,GÜNERİ Pelin Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. , 2022, ss.175 - 181. 10.4274/meandros.galenos.2021.16046
AMA	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. . 2022; 175 - 181. 10.4274/meandros.galenos.2021.16046
Vancouver	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. . 2022; 175 - 181. 10.4274/meandros.galenos.2021.16046
IEEE	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P "Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study." , ss.175 - 181, 2022. 10.4274/meandros.galenos.2021.16046
ISNAD	ÖZER, Nezaket Ezgi vd. "Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study". (2022), 175-181. https://doi.org/10.4274/meandros.galenos.2021.16046

APA	ÖZER N, KARACA B, gürhan c, BOYACIOĞLU H, AYKUTLU U, GÜNERİ P (2022). Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal, 23(2), 175 - 181. 10.4274/meandros.galenos.2021.16046
Chicago	ÖZER Nezaket Ezgi,KARACA Betül,gürhan ceyda,BOYACIOĞLU Hayal,AYKUTLU Umut,GÜNERİ Pelin Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal 23, no.2 (2022): 175 - 181. 10.4274/meandros.galenos.2021.16046
MLA	ÖZER Nezaket Ezgi,KARACA Betül,gürhan ceyda,BOYACIOĞLU Hayal,AYKUTLU Umut,GÜNERİ Pelin Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal, vol.23, no.2, 2022, ss.175 - 181. 10.4274/meandros.galenos.2021.16046
AMA	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal. 2022; 23(2): 175 - 181. 10.4274/meandros.galenos.2021.16046
Vancouver	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study. Meandros Medical And Dental Journal. 2022; 23(2): 175 - 181. 10.4274/meandros.galenos.2021.16046
IEEE	ÖZER N,KARACA B,gürhan c,BOYACIOĞLU H,AYKUTLU U,GÜNERİ P "Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study." Meandros Medical And Dental Journal, 23, ss.175 - 181, 2022. 10.4274/meandros.galenos.2021.16046
ISNAD	ÖZER, Nezaket Ezgi vd. "Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study". Meandros Medical And Dental Journal 23/2 (2022), 175-181. https://doi.org/10.4274/meandros.galenos.2021.16046