Objective: Individuals with autism spectrum disorder (ASD) who engage in minimal physical exercise may experience epileptic seizures as a result of impaired motor development. The aim of this study was to examine the correlation between regular physical activity and physical fitness, and epileptic seizures. Material and Methods: The study included 30 males with ASD, aged 11 to 14, who received inclusive education from 9 schools and experienced at least 5 epileptic seizures each week. The study is based participants being ran- domly assigned to 1 of 2 groups: Land (n=15; Xyears=12.53±1.25) or water (n=15; Xyears=12.27±1.10). A 45-minute physical activity was provided 2 days a week to the land group only on land and to the water group only in the water for 26 weeks. Physical fitness was measured using the Brockport Physical Fitness Test, and the number of epileptic seizures was assessed by family and teacher observations. The Shapiro- Wilk test and descriptive statistics were employed to determine the nor- mality distribution of the data. The difference between groups was determined using an independent sample t-test, the within-group dif- ference was determined using a dependent sample t-test. Results: Dis- covered a correlation between a 26-week regular physical exercise program and physical fitness components as well a reduction in epilep- tic seizures. It was suggested that land-based physical activities en- hanced aerobic endurance, arm strength, abdominal strength, and flexibility attributes more than water-based exercises, whereas water-based exercises were more helpful in lowering epileptic episodes. Conclusion: The results provide essential information for assessing physical fitness and epileptic seizures in young people with ASD, and it is believed that incorporating physical exercise into daily life will have a positive impact on physical fitness and epileptic seizures.