Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients
Yıl: 2022 Cilt: 31 Sayı: 3 Sayfa Aralığı: 250 - 256 Metin Dili: İngilizce DOI: 10.5152/turkjnephrol.2022.21075 İndeks Tarihi: 19-07-2022
Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients
Öz: Objective: Inflammation and oxidative stress are the 2 well-known physiopathological processes involved in the onset
and progression of atherosclerosis and can play role in the poor prognosis of kidney transplantation. However, there is
no satisfactory evidence for their markers to be used for the diagnosis and/or follow-up of cardiovascular disease in daily
practice. We aimed to investigate inflammation and oxidative stress markers in kidney transplant recipients long after
transplantation.
Methods: This study was carried out with 62 kidney transplant recipients (34 females and 28 males) who had received a
successful transplant at least before 6 months. A group of 50 healthy individuals (28 females and 22 males) were selected
as controls.
Results: Homocysteine, advanced glycation end products, high sensitivity C-reactive protein, insulin-like growth factor-1,
protein S-100B, and vitamin A levels were higher; vitamin E levels and paraoxonase and arylesterase activities were significantly lower in kidney transplant recipients.
Conclusion: Kidney transplant recipients are exposed to inflammation and oxidative stress a long time after kidney transplantation. These processes initiated by the body in order to defend itself may damage the tissues after a certain stage, so
further studies investigating treatment strategies for reducing inflammation and oxidative stress load and their effects on
the prognosis of kidney transplant recipients are needed.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Recio-Mayoral A, Banerjee D, Streather C, Kaski JC. Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease – a cross-sectional study of predialysis, dialysis and kidne y-transplantation patients. Atherosclerosis. 2011;216(2):446-451. [CrossRef]
- 2. Cozlea DL, Farcas DM, Nagy A, et al. The impact of C reactive protein on global cardiovascular risk on patients with coronary artery disease. Curr Health Sci J. 2013;39(4):225-231.
- 3. Liu X, Liu K, Wang Z, et al. Advanced glycation end products accelerate arteriosclerosis after renal transplantation through the AGE/RAGE/ILK pathway. Exp Mol Pathol. 2015;99(2):312-319. [CrossRef]
- 4. DaffuG, del PozoCH, O'SheaKM, AnanthakrishnanR, RamasamyR, Schmidt AM. Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int J Mol Sci. 2013;14(10):19891-19910. [CrossRef]
- 5. Lioudaki S, Verikokos C, Kouraklis G, et al. Paraoxonase-1: characteristics and role in atherosclerosis and carotid artery disease. Curr Vasc Pharmacol. 2019;17(2):141-146. [CrossRef]
- 6. Wallert M, Schmölz L, Galli F, Birringer M, Lorkowski S. Regulatory metabolites of vitamin E and their putative relevance for atherogenesis. Redox Biol. 2014;2(2):495-503. [CrossRef]
- 7. Sztanek F, Seres I, Harangi M, et al. Decreased paraoxonase 1 (PON1) lactonase activity in hemodialyzed and renal transplanted patients. A novel cardiovascular biomarker in end-stage renal disease. Nephrol Dial Transplant. 2012;27(7):2866-2872. [CrossRef]
- 8. Janda K, Aksamit D, Drozdz M, et al. Influence of elevated homocystein level and selected lipid parameters in kidney transplant patients on the progression of atherosclerotic changes assessed by intima-media thickness index (CCA-IMT). Przegl Lek. 2012;69(9):670-674.
- 9. Conti E, Carrozza C, Capoluongo E, et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation. 2004;110(15):2260- 2265. [CrossRef]
- 10. Kawachi S, TakedaN, Sasaki A, et al. Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2005;25(3):617-621. [CrossRef]
- 11. Eckerson HW, Wyte CM, La Du BN. The human serum paraoxonas e/arylesterase polymorphism. Am J Hum Genet. 1983;35(6): 1126-1138.
- 12. Haagen L, Brock A. A new automated method for phenotyping arylesterase (E.C.3.1.1.2.) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clin Biochem. 1992;30(7):391-395. [CrossRef]
- 13. Sotomayor CG, Gomes-Neto AW, van Londen M, et al. Circulating advanced glycation endproducts and long-term risk of cardiovascular mortality in kidney transplant recipients. Clin J Am Soc Nephrol. 2019;14(10):1512-1520. [CrossRef]
- 14. Sebeková K, Klenovicsová K, Ferenczová J, Hedvig J, Podracká L, Heidland A. Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency. J Ren Nutr. 2012;22(1):143-148. [CrossRef]
- 15. Padi SS, Chopra K. Salvage of cyclosporine a induced oxidative stress and renal dysfunction by carvedilol. Nephron. 2002;92(3):685- 692. [CrossRef]
- 16. Bansal S, Chawla D, Siddarth M, Banerjee BD, Madhu SV, Tripathi AK. A study on serum advanced glycation end products and its association with oxidative stress and paraoxonase activity in type 2 diabetic patients with vascular complications. Clin Biochem. 2013;46(1-2):109-114. [CrossRef]
- 17. Locsey L, Seres I, Sztanek F, et al. Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients. Transplant Proc. 2013;45(10):3685-3687. [CrossRef]
- 18. Monfared A, Azimi SZ, Kazemnezhad E, et al. Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran. Transplantation. 2014;98(1):66-71. [CrossRef]
- 19. Einollahi B, Lessan-Pezeshki M, Kalantar E, et al. Hyperhomocysteinemia after kidney transplantation. Transplant Proc. 2011;43(2):586-587. [CrossRef]
- 20. Jing J, IsoherranenN, Robinson-Cohen C, Petrie I, Kestenbaum BR, Yeung CK. Chronic kidney disease alters vitamin A homeostasis via effects on hepatic RBP4 protein expression and metabolic enzymes. Clin Transl Sci. 2016;9(4):207-215. [CrossRef]
- 21. Henze A, Raila J, Kempf C, et al. Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study. Lipids Health Dis. 2011;10:231. [CrossRef]
- 22. Fellah H, Feki M, Souissi M, et al. Oxidative stress in end stage renal disease: evidence and association with cardiovascular events in Tunisian patients. Tunis Med. 2006;84(11):724-729.
- 23. Connolly GM, Cunningham R, Maxwell AP, Young IS. Decreased serum retinol is associated with increased mortality in renal transplant recipients. Clin Chem. 2007;53(10):1841-1846. [CrossRef]
- 24. Gross S, Homan van der Heide JJ, van Son WJ, et al. Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients. Med Sci Monit. 2010;16(7):CR318-CR324.
- 25. Unal A, Ata S, Karakurkcu C, et al. Does renal tubular injuryinduced local tissue hypoxia involve post-transplantation erythrocytosis? Transplant Proc. 2017;49(8):1930-1934. [CrossRef]
- 26. Arbeiter AK, Büscher R, Petersenn S, Hauffa BP, Mann K, Hoyer PF. Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation. Nephrol Dial Transplant. 2009;24(2):643- 646. [CrossRef]
- 27. Juul A, Scheike T, Davidsen M, Gyllenborg J, Jørgensen T. Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation. 2002;106(8):939-944. [CrossRef]
- 28. Kaplan RC, Strickler HD, Rohan TE, Muzumdar R, Brown DL. Insulin-like growth factors and coronary heart disease. Cardiol Rev. 2005;13(1):35-39. [CrossRef]
- 29. Faupel-Badger JM, Berrigan D, Ballard-Barbash R, Potischman N. Anthropometric correlates of insulin-like growth factor 1 (IGF-1) and IGF binding protein-3 (IGFBP-3) levels by race/ethnicity and gender. Ann Epidemiol. 2009;19(12):841-849. [CrossRef]
- 30. Lukanova A, Lundin E, Zeleniuch-Jacquotte A, et al. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGFbinding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol. 2004;150(2):161-171. [CrossRef]
| APA | Dirican M, Kirhan E, KOCA N, Baloglu Kacan S, ERSOY A, Sarandöl E (2022). Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. , 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| Chicago | Dirican Melahat,Kirhan Emine,KOCA Nizameddin,Baloglu Kacan Selen,ERSOY ALPARSLAN,Sarandöl Emre Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. (2022): 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| MLA | Dirican Melahat,Kirhan Emine,KOCA Nizameddin,Baloglu Kacan Selen,ERSOY ALPARSLAN,Sarandöl Emre Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. , 2022, ss.250 - 256. 10.5152/turkjnephrol.2022.21075 |
| AMA | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. . 2022; 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| Vancouver | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. . 2022; 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| IEEE | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E "Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients." , ss.250 - 256, 2022. 10.5152/turkjnephrol.2022.21075 |
| ISNAD | Dirican, Melahat vd. "Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients". (2022), 250-256. https://doi.org/10.5152/turkjnephrol.2022.21075 |
| APA | Dirican M, Kirhan E, KOCA N, Baloglu Kacan S, ERSOY A, Sarandöl E (2022). Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. Turkish journal of nephrology (Online), 31(3), 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| Chicago | Dirican Melahat,Kirhan Emine,KOCA Nizameddin,Baloglu Kacan Selen,ERSOY ALPARSLAN,Sarandöl Emre Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. Turkish journal of nephrology (Online) 31, no.3 (2022): 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| MLA | Dirican Melahat,Kirhan Emine,KOCA Nizameddin,Baloglu Kacan Selen,ERSOY ALPARSLAN,Sarandöl Emre Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. Turkish journal of nephrology (Online), vol.31, no.3, 2022, ss.250 - 256. 10.5152/turkjnephrol.2022.21075 |
| AMA | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. Turkish journal of nephrology (Online). 2022; 31(3): 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| Vancouver | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients. Turkish journal of nephrology (Online). 2022; 31(3): 250 - 256. 10.5152/turkjnephrol.2022.21075 |
| IEEE | Dirican M,Kirhan E,KOCA N,Baloglu Kacan S,ERSOY A,Sarandöl E "Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients." Turkish journal of nephrology (Online), 31, ss.250 - 256, 2022. 10.5152/turkjnephrol.2022.21075 |
| ISNAD | Dirican, Melahat vd. "Inflammation and Oxidative Stress Markers and Their Relationship in Kidney Transplant Recipients". Turkish journal of nephrology (Online) 31/3 (2022), 250-256. https://doi.org/10.5152/turkjnephrol.2022.21075 |
