Evaluation of 25-hydroxyvitamin D levels in obese
individuals

İNANÇ, Neriman; Unluhizarci, Kursad; Başmısırlı, Eda; Kaner, Gülşah

doi:10.4274/gulhane.galenos.2021.46036

Evaluation of 25-hydroxyvitamin D levels in obese individuals

Gülşah KANER, (İzmir Katip Çelebi Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, İzmir, Türkiye)

Neriman İNANÇ, (Nuh Naci Yazgan Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Kayseri, Türkiye)

Eda BAŞMISIRLI, (Nuh Naci Yazgan Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Kayseri, Türkiye)

Kürşad ÜNLÜHIZARCI (Erciyes Üniversitesi, Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Kayseri, Türkiye)

Gülhane Tıp Dergisi

0 0

Yıl: 2022 Cilt: 64 Sayı: 2 Sayfa Aralığı: 152 - 158 Metin Dili: İngilizce DOI: 10.4274/gulhane.galenos.2021.46036 İndeks Tarihi: 19-07-2022

Evaluation of 25-hydroxyvitamin D levels in obese individuals

Öz:

Aims: Although 25-hydroxyvitamin D [25(OH)D] deficiency is common, only a few studies have focused on the 25(OH)D level in obese people in Turkey. Therefore, this study assessed the relationship between 25(OH)D status and obesity in the Kayseri region in Turkey. Methods: This cross-sectional study included otherwise healthy individuals aged 20 to 49 years. Obesity was defined as body mass index (BMI) ≥30. A bioelectrical impedance analyzer was used to measure the body composition. The short form of the “International Physical Activity Questionnaire” was used to assess the physical activity level. Blood 25(OH)D and parathyroid hormone (PTH) levels, dietary intake, body composition, and potential factors associated with the 25(OH)D status were determined. Results: The study included 268 adults (mean age: 31.4±9.5 years, 69.5% were women). The proportion of vitamin D deficiency (<20 ng/mL) was 84.3% and 83.5% in the obese and normalweight individuals, respectively. Obese individuals had lower 25(OH)D level [11.6 (8.1-17.9) vs. 13.5 (9.7-18.3) ng/mL, p=0.069] and higher PTH level [44 (35.0-63.0) vs. 36 (28.0-47.0) pg/mL, p<0.001] compared with their normal-weight counterparts. Dietary vitamin D and calcium intake were similar, whereas phosphorous intake was higher in the obese subjects [1052.7 (754.9-1118.4) vs. 945.7 (754.9-1118.4) mg/day p=0.015]. 25(OH)D levels correlated with BMI (p<0.001, r=-0.170), body fat mass (p<0.01, r=-0.179), and muscle mass (p<0.001, r=0.251). Conclusions: 25(OH)D deficiency is common among obese and normal-weight individuals in this large middle Anatolian city of Turkey. This study found a relationship between serum 25(OH)D levels and BMI, body fat, and muscle mass in the study sample.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what 7 clinicians need to know. J Clin Endocrinol Metab. 2011;96:53-58.
2. Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep. 2013;13:261-270.
3. Vimaleswaran KS, Cavadino A, Berry DJ, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014;2:719-729.
4. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and metaanalysis. Maturitas. 2010;65:225-236.
5. Samuel L, Borrell LN. The effect of body mass index on adequacy of serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey 2001 to 2006. Ann Epidemiol. 2014;24:781-784.
6. Mai XM, Chen Y, Camargo CA Jr, Langhammer A. Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. Am J Epidemiol. 2012;175:1029-1036.
7. Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes (Lond). 2012;36:387-396.
8. Mason RS, Sequeira VB, Gordon-Thomson C. Vitamin D: the light side of sunshine. Eur J Clin Nutr. 2011;65:986-993.
9. Aypak C, Yıkılkan H, Dicle M, Önder Ö, Görpelioğlu S. The relationship of vitamin D status with body mass index among obese adults. Med Bull Haseki. 2013;51:95-98.
10. Tosunbayraktar G, Bas M, Kut A, Buyukkaragoz AH. Low serum 25(OH)D levels are associated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey. Afr Health Sci. 2015;15:1161-1169.
11. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253.
12. Pekcan G. Beslenme Durumunun Saptanması. In: Baysal A, Aksoy M, Besler T, Bozkurt N, Keçecioğlu S et al. (editors). Diyet El Kitabı, 4th ed. Ankara, Turkey: Hatiboglu Yayınevi; 2010;65-117.
13. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157-163.
14. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-1930.
15. The Ministry of Health of Turkey The General Directorate of Primary Health Care. Recommended Safe Level of Intake of Energy and Nutrients for Turkey. In: The Ministry of Health of Turkey The General Directorate of Primary Health Care and Hacettepe University Department of Nutrition and Dietetics (editors). Dietary Guidelines for Turkey, 5th ed. Ankara, Turkey: Onur Matbaacilik; 2006. pp 58-60.
16. Ebispro for Windows, Stuttgart, Germany, BEBİS, Turkish version and Data Bases: Bundeslebenmittelschlüssell, 11.3 and other sources. Nutrition Information Systems, 2004.
17. Rakıcıoglu N, Tek Acar N, Ayaz A, Pekcan G. Yemek ve Besin Fotograf Katalogu: Ölçü ve miktarlar. 2 nd edit. Ankara, Turkey: Ata Ofset Matbaacılık; 2009.
18. Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35:1381-1395.
19. Lagunova Z, Porojnicu AC, Lindberg F, Hexeberg S, Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009;29:3713-3720.
20. Parikh SJ, Edelman M, Uwaifo GI, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004;89:1196-1199.
21. Karlsson T, Andersson L, Hussain A, et al. Lower vitamin D status in obese compared with normal-weight women despite higher vitamin D intake in early pregnancy. Clin Nutr. 2015; 34:892-898.
22. Vishnu K, Indumathi S, Harishkiran NE. The study of association of serum parathyroid hormone level with obesity in subjects admitted to a tertiary care centre. Int J Biomed Res. 2018;9:40-44.
23. Shirazi L, Almquist M, Malm J, Wirfält E, Manjer J. Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH. BMC Womens Health. 2013;13:33.
24. Moy FM, Bulgiba A. High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia. BMC Public Health. 2011;11:735.
25. Brock K, Huang WY, Fraser DR, et al. Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J Steroid Biochem Mol Biol. 2010;121:462-466.
26. Ahern T, Khattak A, O’Malley E, et al. Association between vitamin D status and physical function in the severely obese. J Clin Endocrinol Metab. 2014;99:E1327-E1331.
27. Mathieu SV, Fischer K, Dawson-Hughes B, et al. Association between 25-Hydroxyvitamin D status and components of Body Composition and Glucose Metabolism in Older Men and Women. Nutrients. 2018;10:1826.
28. Oliai Araghi S, van Dijk SC, Ham AC, et al. BMI and Body Fat Mass Is Inversely Associated with Vitamin D Levels in Older Individuals. J Nutr Health Aging. 2015;19:980-985.
29. Jungert A, Neuhäuser-Berthold M. Sex-specific determinants of serum 25-hydroxyvitamin D3 concentrations in an elderly German cohort: a cross-sectional study. Nutr Metab (Lond). 2015;12:2.
30. Shantavasinkul PC, Phanachet P, Puchaiwattananon O, et al. Vitamin D status is a determinant of skeletal muscle mass in obesity according to body fat percentage. Nutrition. 2015;31:801-806.
31. Ko MJ, Yun S, Oh K, Kim K. Relation of serum 25-hydroxyvitamin D status with skeletal muscle mass by sex and age group among Korean adults. Br J Nutr. 2015;114:1838-1844.

APA	Kaner G, İNANÇ N, Başmısırlı E, Unluhizarci K (2022). Evaluation of 25-hydroxyvitamin D levels in obese individuals. , 152 - 158. 10.4274/gulhane.galenos.2021.46036
Chicago	Kaner Gülşah,İNANÇ Neriman,Başmısırlı Eda,Unluhizarci Kursad Evaluation of 25-hydroxyvitamin D levels in obese individuals. (2022): 152 - 158. 10.4274/gulhane.galenos.2021.46036
MLA	Kaner Gülşah,İNANÇ Neriman,Başmısırlı Eda,Unluhizarci Kursad Evaluation of 25-hydroxyvitamin D levels in obese individuals. , 2022, ss.152 - 158. 10.4274/gulhane.galenos.2021.46036
AMA	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K Evaluation of 25-hydroxyvitamin D levels in obese individuals. . 2022; 152 - 158. 10.4274/gulhane.galenos.2021.46036
Vancouver	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K Evaluation of 25-hydroxyvitamin D levels in obese individuals. . 2022; 152 - 158. 10.4274/gulhane.galenos.2021.46036
IEEE	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K "Evaluation of 25-hydroxyvitamin D levels in obese individuals." , ss.152 - 158, 2022. 10.4274/gulhane.galenos.2021.46036
ISNAD	Kaner, Gülşah vd. "Evaluation of 25-hydroxyvitamin D levels in obese individuals". (2022), 152-158. https://doi.org/10.4274/gulhane.galenos.2021.46036

APA	Kaner G, İNANÇ N, Başmısırlı E, Unluhizarci K (2022). Evaluation of 25-hydroxyvitamin D levels in obese individuals. Gülhane Tıp Dergisi, 64(2), 152 - 158. 10.4274/gulhane.galenos.2021.46036
Chicago	Kaner Gülşah,İNANÇ Neriman,Başmısırlı Eda,Unluhizarci Kursad Evaluation of 25-hydroxyvitamin D levels in obese individuals. Gülhane Tıp Dergisi 64, no.2 (2022): 152 - 158. 10.4274/gulhane.galenos.2021.46036
MLA	Kaner Gülşah,İNANÇ Neriman,Başmısırlı Eda,Unluhizarci Kursad Evaluation of 25-hydroxyvitamin D levels in obese individuals. Gülhane Tıp Dergisi, vol.64, no.2, 2022, ss.152 - 158. 10.4274/gulhane.galenos.2021.46036
AMA	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K Evaluation of 25-hydroxyvitamin D levels in obese individuals. Gülhane Tıp Dergisi. 2022; 64(2): 152 - 158. 10.4274/gulhane.galenos.2021.46036
Vancouver	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K Evaluation of 25-hydroxyvitamin D levels in obese individuals. Gülhane Tıp Dergisi. 2022; 64(2): 152 - 158. 10.4274/gulhane.galenos.2021.46036
IEEE	Kaner G,İNANÇ N,Başmısırlı E,Unluhizarci K "Evaluation of 25-hydroxyvitamin D levels in obese individuals." Gülhane Tıp Dergisi, 64, ss.152 - 158, 2022. 10.4274/gulhane.galenos.2021.46036
ISNAD	Kaner, Gülşah vd. "Evaluation of 25-hydroxyvitamin D levels in obese individuals". Gülhane Tıp Dergisi 64/2 (2022), 152-158. https://doi.org/10.4274/gulhane.galenos.2021.46036