PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY

Gürbüz, Melek Kezban; Abakay, Mehmet akif; acikalin, mustafa fuat; Etiz, Durmuş; Pinarbasli, Mehmet Ozgur

PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY

M. Akif ABAKAY, (1Bakırköy Dr Sadi Konuk Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Anabilim Dalı, İstanbul, Türkiye)

Mehmet Özgür PINARBAŞLI, (2Eskişehir Osmangazi Üniversitesi, Kulak Burun Boğaz Anabilim Dalı, Eskişehir, Türkiye)

Melek Kezban GÜRBÜZ, (2Eskişehir Osmangazi Üniversitesi, Kulak Burun Boğaz Anabilim Dalı, Eskişehir, Türkiye)

Durmuş ETİZ, (Eskişehir Osmangazi Üniversitesi Radyasyon Onkolojisi Anabilim Dalı, Radyasyon Onkolojisi, Eskişehir, Türkiye)

Mustafa AÇIKALIN (Eskişehir Osmangazi Üniversitesi Patoloji Anabilim Dalı, Patoloji, Eskişehir, Türkiye)

KBB-Forum

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Yıl: 2022 Cilt: 21 Sayı: 2 Sayfa Aralığı: 57 - 63 Metin Dili: İngilizce İndeks Tarihi: 19-07-2022

PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY

Öz:

Objective: Early-stage glottic laryngeal squamous cell carcinoma has good mortality and morbidity rates with radiotherapy. However, recurrent cases are at risk of increased morbidity and mortality. Therefore, the identification of new prognostic markers is needed. Material and Methods: Forty patients with early-stage glottic carcinoma managed with radiotherapy were included in this study. Immunohistochemical evaluation was performed for Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha from biopsy specimens. The relationship between overall survival and investigated parameters was analyzed by Kaplan-Meier and regression analysis. Results: There were 11 recurrences and 20 deaths occurred during the follow-up period. There was no significant relationship between Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining and overall survival. There were no significant correlations between age, smoking status, differentiation, T stage, and anterior commissure involvement with Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining. Conclusion: It seems pretreatment Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha expression levels do not correlate with overall survival in early-stage glottic carcinoma primarily managed with radiotherapy.

Anahtar Kelime:

RADYOTERAPİ İLE TEDAVİ EDİLEN ERKEN EVRE GLOTTİK LARİNGEAL SKUAMÖZ HÜCRELİ KARSİNOMDA HİPOKSİ İLE İNDÜKLENEBİLİR FAKTÖR 1-ALFA VE NÜKLEER FAKTÖR KAPPA B'NIN PROGNOSTİK ÖNEMİ

Öz:

Giriş: Erken evre glottik laringeal skuamöz hücreli karsinom, radyoterapi ile iyi mortalite ve morbidite oranlarına sahiptir. Bununla birlikte, nüks vakalar artmış morbidite ve mortalite riski altındadır. Bu nedenle yeni prognostik belirteçlerin tanımlanmasına ihtiyaç duyulmuştur. Amaç ve Yöntemler: Bu çalışmaya radyoterapi ile tedavi edilen erken evre glottik karsinomlu kırk hasta dahil edildi. Biyopsi örneklerinden Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa için immünohistokimyasal değerlendirme yapıldı. Genel sağkalım ile araştırılan parametreler arasındaki ilişki Kaplan-Meier ve regresyon analizleri ile analiz edildi. Bulgular: Takip süresince 11 nüks ve 20 ölüm meydana geldi. Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa boyama ve genel sağkalım arasında anlamlı bir ilişki yoktu. Yaş, sigara içme durumu, farklılaşma, T evresi ve ön komissür tutulumu ile Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa boyama arasında anlamlı bir ilişki yoktu. Tartışma ve Sonuçlar: Primer olarak radyoterapi ile tedavi edilen erken evre glottik karsinomda tedavi öncesi Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa ekspresyon düzeylerinin genel sağkalım ile ilişkili olmadığı saptanmıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Abakay M, Pinarbasli M, Gürbüz M, Etiz D, acikalin m (2022). PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. , 57 - 63.
Chicago	Abakay Mehmet akif,Pinarbasli Mehmet Ozgur,Gürbüz Melek Kezban,Etiz Durmuş,acikalin mustafa fuat PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. (2022): 57 - 63.
MLA	Abakay Mehmet akif,Pinarbasli Mehmet Ozgur,Gürbüz Melek Kezban,Etiz Durmuş,acikalin mustafa fuat PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. , 2022, ss.57 - 63.
AMA	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. . 2022; 57 - 63.
Vancouver	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. . 2022; 57 - 63.
IEEE	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m "PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY." , ss.57 - 63, 2022.
ISNAD	Abakay, Mehmet akif vd. "PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY". (2022), 57-63.

APA	Abakay M, Pinarbasli M, Gürbüz M, Etiz D, acikalin m (2022). PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum, 21(2), 57 - 63.
Chicago	Abakay Mehmet akif,Pinarbasli Mehmet Ozgur,Gürbüz Melek Kezban,Etiz Durmuş,acikalin mustafa fuat PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum 21, no.2 (2022): 57 - 63.
MLA	Abakay Mehmet akif,Pinarbasli Mehmet Ozgur,Gürbüz Melek Kezban,Etiz Durmuş,acikalin mustafa fuat PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum, vol.21, no.2, 2022, ss.57 - 63.
AMA	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum. 2022; 21(2): 57 - 63.
Vancouver	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum. 2022; 21(2): 57 - 63.
IEEE	Abakay M,Pinarbasli M,Gürbüz M,Etiz D,acikalin m "PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY." KBB-Forum, 21, ss.57 - 63, 2022.
ISNAD	Abakay, Mehmet akif vd. "PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY". KBB-Forum 21/2 (2022), 57-63.