Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules
Yıl: 2022 Cilt: 33 Sayı: 2 Sayfa Aralığı: 109 - 115 Metin Dili: İngilizce DOI: 10.14744/scie.2022.47154 İndeks Tarihi: 20-07-2022
Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules
Öz: Objective: Fibrinoid accumulation in the larynx and increase in the subepithelial collage-
nous connective tissue result in overgrowth. Mucosal epithelium may proliferate downward
to organize and remove the fibrinoid accumulation. This downward proliferation may cause
an invasive cancer-like image. This study focused on the pathogenesis of the accumulation of
fibrinoid substance and the development mechanism of the associated squamous epithelium
proliferation.
Methods: Five hundred and seventy-five laryngeal nodules were reexamined and 111 of
them with varying degrees of irregular downward squamous epithelial proliferation were
included in the study. Immunohistochemical staining of CK5/6, CK17, CK14, collagen type
I, collagen type III, collagen type IV, and fibrinogen was performed. A modified Masson’s
trichrome method was used for the histochemical staining of collagen.
Results: Edema was present in 18% of the acute lesions and fibrin deposition in 42%. Rela-
tively mature lesions mostly contain dense collagen fibers. The intensity of collagen type III
was inversely proportional to the amount of fibrin accumulation. Collagen type IV was found
in the epithelial and vascular basement membranes. A decrease in fibrin staining intensity
and the presence of collagen type I and type III indicated the replacement of fibrin with col-
lagen. Basal-type keratins showed more pronounced staining in the regenerated areas of the
epithelium. As the laryngeal subepithelial fibrinoid accumulation was replaced with collagen,
regression of the lesion became difficult.
Conclusion: Irregular squamous epithelial proliferation occurs independent of the stage of
the lesion. Although the etiology is different, the resulting lesions are histologically similar to
those seen in the ligneous mucosal disease
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | BAŞAK K, Günhan Ö, Çaputcu M, ARDA Ş, ATLI M, DEMIR D, OĞUZTÜZÜN S (2022). Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. , 109 - 115. 10.14744/scie.2022.47154 |
Chicago | BAŞAK Kayhan,Günhan Ömer,Çaputcu Merve,ARDA Şule Sağlam,ATLI Muharrem,DEMIR DERYA,OĞUZTÜZÜN Serpil Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. (2022): 109 - 115. 10.14744/scie.2022.47154 |
MLA | BAŞAK Kayhan,Günhan Ömer,Çaputcu Merve,ARDA Şule Sağlam,ATLI Muharrem,DEMIR DERYA,OĞUZTÜZÜN Serpil Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. , 2022, ss.109 - 115. 10.14744/scie.2022.47154 |
AMA | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. . 2022; 109 - 115. 10.14744/scie.2022.47154 |
Vancouver | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. . 2022; 109 - 115. 10.14744/scie.2022.47154 |
IEEE | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S "Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules." , ss.109 - 115, 2022. 10.14744/scie.2022.47154 |
ISNAD | BAŞAK, Kayhan vd. "Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules". (2022), 109-115. https://doi.org/10.14744/scie.2022.47154 |
APA | BAŞAK K, Günhan Ö, Çaputcu M, ARDA Ş, ATLI M, DEMIR D, OĞUZTÜZÜN S (2022). Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. Southern Clinics of Istanbul Eurasia, 33(2), 109 - 115. 10.14744/scie.2022.47154 |
Chicago | BAŞAK Kayhan,Günhan Ömer,Çaputcu Merve,ARDA Şule Sağlam,ATLI Muharrem,DEMIR DERYA,OĞUZTÜZÜN Serpil Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. Southern Clinics of Istanbul Eurasia 33, no.2 (2022): 109 - 115. 10.14744/scie.2022.47154 |
MLA | BAŞAK Kayhan,Günhan Ömer,Çaputcu Merve,ARDA Şule Sağlam,ATLI Muharrem,DEMIR DERYA,OĞUZTÜZÜN Serpil Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. Southern Clinics of Istanbul Eurasia, vol.33, no.2, 2022, ss.109 - 115. 10.14744/scie.2022.47154 |
AMA | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. Southern Clinics of Istanbul Eurasia. 2022; 33(2): 109 - 115. 10.14744/scie.2022.47154 |
Vancouver | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules. Southern Clinics of Istanbul Eurasia. 2022; 33(2): 109 - 115. 10.14744/scie.2022.47154 |
IEEE | BAŞAK K,Günhan Ö,Çaputcu M,ARDA Ş,ATLI M,DEMIR D,OĞUZTÜZÜN S "Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules." Southern Clinics of Istanbul Eurasia, 33, ss.109 - 115, 2022. 10.14744/scie.2022.47154 |
ISNAD | BAŞAK, Kayhan vd. "Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules". Southern Clinics of Istanbul Eurasia 33/2 (2022), 109-115. https://doi.org/10.14744/scie.2022.47154 |