Objective: Synthetic cannabinoids are psychoactive substances that mimic the effect of tetrahydrocannabinol in the body via CB1 and CB2 receptors. Information on these fatal adverse effects of synthetic cannabinoids is limited to case reports and large case series. The aim of our study is to contribute to the elucidation of the death mechanism in synthetic cannabinoid-related deaths through the organ pathologies of the cardiovascular and respiratory system organs and to the studies on the prevention of substance use/addiction. Material and Methods: Autopsy reports of cases whose death was attributed to the use of synthetic cannabinoid in the 10-year period between 2010-2019 at the “Council of Forensic Medicine of Trabzon Forensic Medicine Group Department” were analyzed. Blood and urine samples were analyzed via AB-SCIEX 5500 QTRAP model liquid chromatography-mass spectrometry/mass spectrometry device. Results: Twenty-two cases were included in the study. The ages of the cases ranged between 18 and 50 years. The median age was 31, and the mean age was 31.59±9.58. Trauma findings were not found in any of the cases whose forensic autopsies were conducted. The weights of the organs, in particular the lung weights, were found to be increased. In the macroscopic and microscopic examination of the organs, diffuse edema in the lungs was detected in 20 (90.9%) cases. In the microscopic examination of the lungs; Intraalveolar hemorrhage in 8 (36.4%) cases, atelectasis in 6 (27.3%) cases, pneumonia in 3 (13.6%) cases, and siderophages in 2 (9.1%) cases were observed. Conclusion: Narcotic drug use is a serious public health concern across the world. Considering the data in both this study and other studies in the literature, an increase in lung weights can be defined as a serious finding in synthetic cannabinoid-related deaths, albeit it is not a specific finding.