Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey

Yıl: 2022 Cilt: 26 Sayı: 2 Sayfa Aralığı: 79 - 84 Metin Dili: İngilizce DOI: 10.5152/tjem.2022.22031 İndeks Tarihi: 21-07-2022

Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey

Öz:
Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data on vitamin D levels from 33 tertiary care hospitals’ clinical biochemistry laboratories around Turkey between January and December were collected. Results: In total, 706 434 serum samples from adult subjects (female/male: 469 028/237 406; 66.4%/33.6%) were included. While vitamin D levels were sufficient in 20.3% (n = 14 222), they were insufficient in 21.9% (n = 154 360) and deficient in 57.8% (n = 408 882). We observed the highest rates of deficiency in those aged between 18 and 29 years (62.9%, n = 70 235) and lowest rates between 60 and 69 years (52.3%, n = 61 121) and between 70 and 79 years (52.3%, n = 32 397). Hypervitaminosis D was detected in 5.5% of adult subjects; highest rates of hypervitaminosis D were observed in those who were over 80 years (6.6%) and 70-79 years (6.5%) and the lowest in 18-29 years (2.8%). Discussion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency and required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Hilger J, Friedel A, Herr R, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014;111(1):23-45. [CrossRef]
  • 2. Zhang W, Stoecklin E, Eggersdorfer M. A glimpse of vitamin D status in Mainland China. Nutrition. 2013;29(7-8):953-957. [CrossRef]
  • 3. Schleicher RL, Sternberg MR, Lacher DA, et al. The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases. Am J Clin Nutr. 2016;104(2):454-461. [CrossRef]
  • 4. Schleicher RL, Sternberg MR, Looker AC, et al. National estimates of serum total 25-hydroxyvitamin D and metabolite concentrations measured by liquid chrom atogr aphy- tande m mass spectrometry in the US population during 2007-2010. J Nutr. 2016;146(5):1051-1061. [CrossRef]
  • 5. Giustina A, Bouillon R, Binkley N, et al. Controversies in vitamin D: a statement from the third international conference. JBMR Plus. 2020;4(12):e10417. [CrossRef]
  • 6. Cashman KD, van den Heuvel EG, Schoemaker RJ, Prévéraud DP, Macdonald HM, Arcot J. 25-Hydroxyvitamin D as a biomarker of vitamin D status and its modeling to inform strategies for prevention of vitamin D deficiency within the population. Adv Nutr. 2017;8(6):947-957. [CrossRef]
  • 7. Sarafin K, Durazo-Arvizu R, Tian L, et al. Standardizing 25-hydroxyvitamin D values from the Canadian Health Measures Survey. Am J Clin Nutr. 2015;102(5):1044-1050. [CrossRef]
  • 8. Alpdemir M, Alpdemir MF. Vitamin D deficiency status in Turkey: a metaanalysis. Int J Med Lab. 2019;2:118.
  • 9. Arnljots R, Thorn J, Elm M, Moore M, Sundvall PD. Vitamin D deficiency was common among nursing home residents and associated with dementia: a cross sectional study of 545 Swedish nursing home residents. BMC Geriatr. 2017;17(1):229. [CrossRef]
  • 10. Haliloğlu Ö, Kasaci T, Yavuz D. Seasonal vitamin D status and endothelial function in healthcare workers. Turk J Med Sci. 2016;46(1):72-78. [CrossRef]
  • 11. Günhan HG, Uygur MM, İmre E, Elbasan O, Gogas Yavuz D. Serum 25(OH) vitamin D levels in severely obese patients evaluated Before bariatric surgery. Turk J Endocrinol Metab. 2020;24(2):115-121. [CrossRef]
  • 12. Muscogiuri G, Barrea L, Somma CD, et al. Sex differences of vitamin D status across BMI classes: an observational prospective cohort study. Nutrients. 2019;11(12). [CrossRef]
  • 13. Youssef DA, Ranasinghe T, Grant WB, Peiris AN. Vitamin D’s potential to reduce the risk of hospital-acquired infections. Derm Endocrinol. 2012;4(2):167-175. [CrossRef]
  • 14. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-1930. [CrossRef]
  • 15. Beirne A, McCarroll K, Walsh JB, et al. Vitamin D and hospital admission in older adults: a prospective association. Nutrients. 2021;13(2). [CrossRef]
  • 16. Rai CK, Shrestha B, Sapkota J, Das JK. Prevalence of vitamin D deficiency among adult patients in A tertiary Care Hospital. JNMA J Nepal Med Assoc. 2019;57(218):226-228. [CrossRef]
  • 17. Amrein K, Zajic P, Schnedl C, et al. Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit Care. 2014;18(2):R47. [CrossRef]
  • 18. Bawaskar PH, Bawaskar HS, Bawaskar PH, Pakhare AP. Profile of vitamin D in patients attending at general hospital Mahad India. Indian J Endocrinol Metab. 2017;21(1):125-130. [CrossRef]
  • 19. Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011;31(1):48-54. [CrossRef]
  • 20. Amrein K, Scherkl M, Hoffmann M, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498- 1513. [CrossRef]
  • 21. Sezgin G, Ozturk G, Turkal R, Caykara B. Vitamin D levels of outpatients admitted to a University Hospital in the Marmara region of Turkey over 3 years. J Med Biochem. 2019;38(2):181-187. [CrossRef]
  • 22. Binkley N, Ramamurthy R, Krueger D. Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am. 2010;39(2):287-301. [CrossRef]
  • 23. Marci nowsk a-Suc howie rska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D toxicity-A clinical perspective. Front Endocrinol (Lausanne). 2018;9:550. [CrossRef]
  • 24. Giustina A, Adler RA, Binkley N, et al. Consensus statement from 2(nd) International Conference on Controversies in vitamin D. Rev Endocr Metab Disord. 2020;21(1):89-116. [CrossRef]
  • 25. Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033-1044. [CrossRef]
  • 26. Basile M, Ciardi L, Crespi I, Saliva E, Bellomo G, Vidali M. Assessing serum concentrations of 25-hydroxy-vitamin D in North-Western Italy. J Frailty Aging. 2013;2(4):174-178. [CrossRef]
  • 27. Cashman KD, Dowling KG, Škrabáková Z, et al. Standardizing serum 25-hydroxyvitamin D data from four Nordic population samples using the vitamin D Standardization Program protocols: shedding new light on vitamin D status in Nordic individuals. Scand J Clin Lab Investig. 2015;75(7):549-561. [CrossRef]
  • 28. Delos Reyes J, Smyth A, Griffin D, O’Shea P, O’Keeffe S, Mulkerrin EC. Vitamin D deficiency and insufficiency prevalence in the west of Ireland - A retrospective study. J Nutr Health Aging. 2017;21(10):1107-1110. [CrossRef]
  • 29. Park JH, Hong IY, Chung JW, Choi HS. Vitamin D status in South Korean population: seven-year trend from the KNHANES. Med (Baltim). 2018;97(26):e11032. [CrossRef]
  • 30. Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr. 2011;29(2):149-155. [CrossRef]
  • 31. Yu HJ, Kwon MJ, Woo HY, Park H. Analysis of 25-hydroxyvitamin D status according to age, gender, and seasonal variation. J Clin Lab Anal. 2016;30(6):905-911. [CrossRef]
  • 32. Levis S, Gomez A, Jimenez C, et al. Vitamin D deficiency and seasonal variation in an adult South Florida population. J Clin Endocrinol Metab. 2005;90(3):1557-1562. [CrossRef]
  • 33. Bhattoa HP, Bettembuk P, Ganacharya S, Balogh A. Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. Osteoporos Int. 2004;15(6):447-451. [CrossRef]
  • 34. Snellman G, Melhus H, Gedeborg R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010;5(7):e11555. [CrossRef]
APA Gogas Yavuz D, Ersoy R, Altuntaş Y, BİLEN H, PAMUK B, apaydin t, Temizkan S, ALTUNTAŞ H, Mert M, AKALIN A, Sert M, ŞİMŞİR I, Hekimsoy Z, canturk z, ALPHAN ÜÇ Z, İPLİKÇİ S, YAŞAR M, ünübol m, Sezer K, Topaloğlu Ö, Turhan İyidir Ö, pekkolay z, ATMACA A, dikbaş o, Ozdemir N, gül k, DENIZ F, ERTÖER E, karaca Z, Elbuken G, ARPACI D, Ağbaht K, turan e, ANAFOROĞLU İ, BAYRAKTAROĞLU T, Haklar G, DAĞLIOĞLU G, TUZCU A, Şahin İ, ÇETİNALP Ş (2022). Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. , 79 - 84. 10.5152/tjem.2022.22031
Chicago Gogas Yavuz Dilek,Ersoy Reyhan,Altuntaş Yüksel,BİLEN Habip,PAMUK Barış,apaydin tugce,Temizkan Sule,ALTUNTAŞ Hasan,Mert Meral,AKALIN AYSEN,Sert Murat,ŞİMŞİR Ilgın YILDIRIM,Hekimsoy Zeliha,canturk zeynep,ALPHAN ÜÇ ZİYNET,İPLİKÇİ Süleyman,YAŞAR MEHMET,ünübol mustafa,Sezer Kerem,Topaloğlu Ömercan,Turhan İyidir Özlem,pekkolay zafer,ATMACA AYSEGUL,dikbaş oğuz,Ozdemir Nilufer,gül kamile,DENIZ FERRAT,ERTÖER Eda,karaca Zuleyha,Elbuken Gulsah,ARPACI Dilek,Ağbaht Kemal,turan elif,ANAFOROĞLU İnan,BAYRAKTAROĞLU TANER,Haklar Goncagul,DAĞLIOĞLU GÜLÇİN,TUZCU ALPASLAN KEMAL,Şahin İbrahim,ÇETİNALP Şevki Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. (2022): 79 - 84. 10.5152/tjem.2022.22031
MLA Gogas Yavuz Dilek,Ersoy Reyhan,Altuntaş Yüksel,BİLEN Habip,PAMUK Barış,apaydin tugce,Temizkan Sule,ALTUNTAŞ Hasan,Mert Meral,AKALIN AYSEN,Sert Murat,ŞİMŞİR Ilgın YILDIRIM,Hekimsoy Zeliha,canturk zeynep,ALPHAN ÜÇ ZİYNET,İPLİKÇİ Süleyman,YAŞAR MEHMET,ünübol mustafa,Sezer Kerem,Topaloğlu Ömercan,Turhan İyidir Özlem,pekkolay zafer,ATMACA AYSEGUL,dikbaş oğuz,Ozdemir Nilufer,gül kamile,DENIZ FERRAT,ERTÖER Eda,karaca Zuleyha,Elbuken Gulsah,ARPACI Dilek,Ağbaht Kemal,turan elif,ANAFOROĞLU İnan,BAYRAKTAROĞLU TANER,Haklar Goncagul,DAĞLIOĞLU GÜLÇİN,TUZCU ALPASLAN KEMAL,Şahin İbrahim,ÇETİNALP Şevki Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. , 2022, ss.79 - 84. 10.5152/tjem.2022.22031
AMA Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. . 2022; 79 - 84. 10.5152/tjem.2022.22031
Vancouver Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. . 2022; 79 - 84. 10.5152/tjem.2022.22031
IEEE Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş "Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey." , ss.79 - 84, 2022. 10.5152/tjem.2022.22031
ISNAD Gogas Yavuz, Dilek vd. "Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey". (2022), 79-84. https://doi.org/10.5152/tjem.2022.22031
APA Gogas Yavuz D, Ersoy R, Altuntaş Y, BİLEN H, PAMUK B, apaydin t, Temizkan S, ALTUNTAŞ H, Mert M, AKALIN A, Sert M, ŞİMŞİR I, Hekimsoy Z, canturk z, ALPHAN ÜÇ Z, İPLİKÇİ S, YAŞAR M, ünübol m, Sezer K, Topaloğlu Ö, Turhan İyidir Ö, pekkolay z, ATMACA A, dikbaş o, Ozdemir N, gül k, DENIZ F, ERTÖER E, karaca Z, Elbuken G, ARPACI D, Ağbaht K, turan e, ANAFOROĞLU İ, BAYRAKTAROĞLU T, Haklar G, DAĞLIOĞLU G, TUZCU A, Şahin İ, ÇETİNALP Ş (2022). Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. Turkish Journal of Endocrinology and Metabolism, 26(2), 79 - 84. 10.5152/tjem.2022.22031
Chicago Gogas Yavuz Dilek,Ersoy Reyhan,Altuntaş Yüksel,BİLEN Habip,PAMUK Barış,apaydin tugce,Temizkan Sule,ALTUNTAŞ Hasan,Mert Meral,AKALIN AYSEN,Sert Murat,ŞİMŞİR Ilgın YILDIRIM,Hekimsoy Zeliha,canturk zeynep,ALPHAN ÜÇ ZİYNET,İPLİKÇİ Süleyman,YAŞAR MEHMET,ünübol mustafa,Sezer Kerem,Topaloğlu Ömercan,Turhan İyidir Özlem,pekkolay zafer,ATMACA AYSEGUL,dikbaş oğuz,Ozdemir Nilufer,gül kamile,DENIZ FERRAT,ERTÖER Eda,karaca Zuleyha,Elbuken Gulsah,ARPACI Dilek,Ağbaht Kemal,turan elif,ANAFOROĞLU İnan,BAYRAKTAROĞLU TANER,Haklar Goncagul,DAĞLIOĞLU GÜLÇİN,TUZCU ALPASLAN KEMAL,Şahin İbrahim,ÇETİNALP Şevki Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. Turkish Journal of Endocrinology and Metabolism 26, no.2 (2022): 79 - 84. 10.5152/tjem.2022.22031
MLA Gogas Yavuz Dilek,Ersoy Reyhan,Altuntaş Yüksel,BİLEN Habip,PAMUK Barış,apaydin tugce,Temizkan Sule,ALTUNTAŞ Hasan,Mert Meral,AKALIN AYSEN,Sert Murat,ŞİMŞİR Ilgın YILDIRIM,Hekimsoy Zeliha,canturk zeynep,ALPHAN ÜÇ ZİYNET,İPLİKÇİ Süleyman,YAŞAR MEHMET,ünübol mustafa,Sezer Kerem,Topaloğlu Ömercan,Turhan İyidir Özlem,pekkolay zafer,ATMACA AYSEGUL,dikbaş oğuz,Ozdemir Nilufer,gül kamile,DENIZ FERRAT,ERTÖER Eda,karaca Zuleyha,Elbuken Gulsah,ARPACI Dilek,Ağbaht Kemal,turan elif,ANAFOROĞLU İnan,BAYRAKTAROĞLU TANER,Haklar Goncagul,DAĞLIOĞLU GÜLÇİN,TUZCU ALPASLAN KEMAL,Şahin İbrahim,ÇETİNALP Şevki Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. Turkish Journal of Endocrinology and Metabolism, vol.26, no.2, 2022, ss.79 - 84. 10.5152/tjem.2022.22031
AMA Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. Turkish Journal of Endocrinology and Metabolism. 2022; 26(2): 79 - 84. 10.5152/tjem.2022.22031
Vancouver Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey. Turkish Journal of Endocrinology and Metabolism. 2022; 26(2): 79 - 84. 10.5152/tjem.2022.22031
IEEE Gogas Yavuz D,Ersoy R,Altuntaş Y,BİLEN H,PAMUK B,apaydin t,Temizkan S,ALTUNTAŞ H,Mert M,AKALIN A,Sert M,ŞİMŞİR I,Hekimsoy Z,canturk z,ALPHAN ÜÇ Z,İPLİKÇİ S,YAŞAR M,ünübol m,Sezer K,Topaloğlu Ö,Turhan İyidir Ö,pekkolay z,ATMACA A,dikbaş o,Ozdemir N,gül k,DENIZ F,ERTÖER E,karaca Z,Elbuken G,ARPACI D,Ağbaht K,turan e,ANAFOROĞLU İ,BAYRAKTAROĞLU T,Haklar G,DAĞLIOĞLU G,TUZCU A,Şahin İ,ÇETİNALP Ş "Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey." Turkish Journal of Endocrinology and Metabolism, 26, ss.79 - 84, 2022. 10.5152/tjem.2022.22031
ISNAD Gogas Yavuz, Dilek vd. "Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey". Turkish Journal of Endocrinology and Metabolism 26/2 (2022), 79-84. https://doi.org/10.5152/tjem.2022.22031