Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme
Yıl: 2022 Cilt: 11 Sayı: 2 Sayfa Aralığı: 152 - 158 Metin Dili: Türkçe DOI: 10.5336/pharmsci.2021-87716 İndeks Tarihi: 21-07-2022
Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme
Öz: İlaçlar, önemli çevresel kirleticiler arasında yer almaktadırlar.
Antidepresan ilaçlar, hem yer altı hem de yer üstü sularında sıklıkla
rastlanan kontaminantlardır. Antidepresan ilaçların su canlılarında tespit edilmesinin 2 nedeni vardır. Birincisi dünya genelinde yaygın kullanımları, ikincisi ise su canlılarının farklı dokularında birikmeleridir.
Bazı balıklar ve yumuşakçalar gibi endemik su hayvanları, dokularında
biyolojik olarak farklı antidepresanları biriktirmektedirler. Bu nedenle
hedef olmayan birçok organizmayı etkileme potansiyeline sahiptirler.
Antidepresanlar, dopamin, norepinefrin ve serotonin gibi nörotransmitterlerle etkileşime girerek santral sinir sistemini doğrudan etkileyen
ilaçlardır. Su canlılarında, bu etkilerinin dışında da etkileri gözlenmektedir. Bu ilaçların dünya çapında artan kullanımına bağlı olarak,
kentsel sularda, yer altı sularında, nehirlerlerde ve okyanuslarda yaygın
tespit edilmektedirler. Ayrıca şu anda mevcut olan atık su arıtma tesisleri, ilaç kalıntılarını uzaklaştıracak şekilde dizayn edilmemiştir. Sulardaki ilaç kontaminasyonu, önümüzdeki yıllarda artacak gibi
görünmektedir. Çünkü mevcut koronavirüs hastalığı-2019 pandemisi,
dünya çapında genel depresyon ve anksiyeteyi tetikleyerek, antidepresan kullanımını ve dolayısıyla çevrede tespit edilen konsantrasyonlarını
artırmıştır. Çevresel ilaç kontaminasyonu, bilimsel belirsizliklerin eşlik
ettiği yaygın bir sorundur. Olası çözümler arasında, ilaçları akılcı kullanmak, çevre dostu ilaçlar reçete etmek, biyolojik olarak daha kolay
parçalanan farmasötikler tasarlamak, çevre ve sağlık bilimleri arasındaki koordinasyonu ve iş birliğini geliştirmek sayılabilir. Bu derlemede,
bazı antidepresanların yer altı ve yer üstü sulardaki kontaminasyonuna
bağlı su canlıları üzerindeki biyoakümülasyonundan ve ekotoksikolojik etkilerinden bahsedilmektedir.
Anahtar Kelime: Risk of Ecotoxicity Due to Bioaccumulation of Antidepressants:Systematic Review
Öz: Drugs are among the important environmental pollutants. Antidepressant drugs are frequently found contaminants in both
ground and surface waters. There are 2 reasons why antidepressant
drugs are detected in aquatic organisms. The first is their widespread
use throughout the world, and the second is their accumulation in different tissues of aquatic organisms. Endemic aquatic animals, such
as some fish and mollusks, accumulate biologically different antidepressants in their tissues. Therefore, they have the potential to affect
many non-target organisms. Antidepressants are drugs that directly
affect the central nervous system by interacting with neurotransmitters such as dopamine, norepinephrine, and serotonin. Apart from
these effects, effects are also observed in aquatic organisms. Due to
the increasing use of these drugs worldwide, they are widely detected
in urban waters, groundwater, rivers and oceans. In addition, currently
existing wastewater treatment plants are not designed to remove drug
residues. Drug contamination in waters is likely to increase in the
coming years. Because the current coronavirus disease-2019 pandemic has triggered general depression and anxiety worldwide, increasing the use of antidepressants and thus their concentrations
detected in the environment. Environmental drug contamination is a
common problem accompanied by scientific uncertainties. Possible
solutions include using drugs rationally, prescribing environmentally
friendly drugs, designing more biodegradable pharmaceuticals, and
improving coordination and collaboration between environmental and
health sciences. In this review, the bioaccumulation and ecotoxicological effects of some antidepressants on aquatic organisms due to
the contamination of underground and surface waters are mentioned.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | yüce h, ünüvar s (2022). Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. , 152 - 158. 10.5336/pharmsci.2021-87716 |
| Chicago | yüce hande,ünüvar songül Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. (2022): 152 - 158. 10.5336/pharmsci.2021-87716 |
| MLA | yüce hande,ünüvar songül Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. , 2022, ss.152 - 158. 10.5336/pharmsci.2021-87716 |
| AMA | yüce h,ünüvar s Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. . 2022; 152 - 158. 10.5336/pharmsci.2021-87716 |
| Vancouver | yüce h,ünüvar s Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. . 2022; 152 - 158. 10.5336/pharmsci.2021-87716 |
| IEEE | yüce h,ünüvar s "Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme." , ss.152 - 158, 2022. 10.5336/pharmsci.2021-87716 |
| ISNAD | yüce, hande - ünüvar, songül. "Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme". (2022), 152-158. https://doi.org/10.5336/pharmsci.2021-87716 |
| APA | yüce h, ünüvar s (2022). Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi, 11(2), 152 - 158. 10.5336/pharmsci.2021-87716 |
| Chicago | yüce hande,ünüvar songül Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi 11, no.2 (2022): 152 - 158. 10.5336/pharmsci.2021-87716 |
| MLA | yüce hande,ünüvar songül Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi, vol.11, no.2, 2022, ss.152 - 158. 10.5336/pharmsci.2021-87716 |
| AMA | yüce h,ünüvar s Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi. 2022; 11(2): 152 - 158. 10.5336/pharmsci.2021-87716 |
| Vancouver | yüce h,ünüvar s Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme. Literatür Eczacılık Bilimleri Dergisi. 2022; 11(2): 152 - 158. 10.5336/pharmsci.2021-87716 |
| IEEE | yüce h,ünüvar s "Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme." Literatür Eczacılık Bilimleri Dergisi, 11, ss.152 - 158, 2022. 10.5336/pharmsci.2021-87716 |
| ISNAD | yüce, hande - ünüvar, songül. "Antidepresanların Biyoakümülasyonuna Bağlı Ekotoksisite Riski: Sistematik Derleme". Literatür Eczacılık Bilimleri Dergisi 11/2 (2022), 152-158. https://doi.org/10.5336/pharmsci.2021-87716 |
