Yıl: 2021 Cilt: 27 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: Türkçe DOI: 10.5505/tbdhd.2021.25348 İndeks Tarihi: 21-07-2022

ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?

Öz:
Büyük damar oklüzyonunun neden olduğu akut iskemik inmede; pıhtının mekanik olarak çıkarıldığı endovasküler girişimler altın standart tedavilerdir. Önceki yıllarda yapılan çalışmaların sonuçlarına ve kılavuz bilgilerine göre günümüzdeki uygulama; eğer hastanın kontrendikasyonu yoksa zaman kaybına yol açmayacak şekilde endovasküler tedavi öncesinde IV rtPA başlanmasıdır. Ancak son yıllarda hastaların direkt anjiyografi ünitesine alınması yönünde eğilimler olup bu iki grubun karşılaştırıldığı randomize kontrollü çalışmalar ağırlık kazanmaktadır. Son çalışmalar içerisinde hastaların direkt olarak endovasküler müdahaleye alınmasının; kombine tedaviden daha kötü olmayabileceğini gösteren sonuçlar da elde edilmiştir. Mevcut çalışmalar ışığında henüz her iki yaklaşım arasında kesin seçimler yapmak mümkün değildir. Bu nedenle her hastayı ayrı ayrı ele alıp hasta bazında en doğru seçimi yapmak daha mantıklı bir yaklaşım olacaktır.
Anahtar Kelime:

SHOULD WE GIVE OR NOT GIVE THROMBOLYTIC THERAPY BEFORE ENDOVASCULAR THERAPY?

Öz:
In acute ischemic stroke due to large vessel occlusion; endovascular interventions in which the clot is removed mechanically are gold standard treatments. According to the guidelines and the results of the studies carried out in previous years, current practice is; If the patient does not have contraindications, IV rtPA is initiated before endovascular treatment without loss of time. However, in recent years there is a tendency in the direction of taking patients directly into the angiography unit and randomized controlled studies comparing these two groups are gaining weight. For direct endovascular intervention of patients; results have also been obtained showing that it may not be worse than combined therapy in recent studies. In the light of current studies, it is not yet possible to make clear choices between both approaches. For this reason, it would be a more logical approach to consider each patient separately and to make the right choice on the basis of the patient.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
0
0
0
  • 1. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 2015; 131(4): e29-e322.
  • 2. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2019; 50(12): e344-e418.
  • 3. Mazighi M, Serfaty J-M, Labreuche J, et al. Comparison of intravenous alteplase with a combined intravenous– endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study. The Lancet Neurology 2009; 8(9): 802-809.
  • 4. Phan K, Dmytriw AA, Maingard J, et al. Endovascular thrombectomy alone versus combined with intravenous thrombolysis. World neurosurgery 2017; 108: 850-858. e2.
  • 5. Disorders NIoN, Group Sr-PSS. Tissue plasminogen activator for acute ischemic stroke. New England Journal of Medicine 1995; 333(24): 1581-1588.
  • 6. Lewandowski CA, Frankel M, Tomsick TA, et al. Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 1999; 30(12): 2598- 2605.
  • 7. Investigators IIT. The interventional management of stroke (IMS) II study. Stroke 2007; 38(7): 2127-2135.
  • 8. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a metaanalysis of individual patient data from five randomised trials. Lancet North Am Ed 2016; 387(10029): 1723-1731.
  • 9. Tsivgoulis GAH, Schellinger PD, Kohrmann M, et al. Successful reperfusion with intravenous thrombolysis preceding mechanical thrombectomy in large-vessel occlusions. Stroke 2018; 49(1): 232-235.
  • 10. Gariel F, Lapergue B, Bourcier R, et al. Mechanical thrombectomy outcomes with or without intravenous thrombolysis. Stroke 2018; 49(10): 2383-2390.
  • 11. Ferrigno M, Bricout N, Leys D, et al. Intravenous recombinant Tissue-Type plasminogen activator. Stroke 2018; 49(6): 1377-1385.
  • 12. Bhatia R, Hill MD, Shobha N, et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action. Stroke 2010; 41(10): 2254- 2258.
  • 13. Rai AT, Boo S, Buseman C, et al. Intravenous thrombolysis before endovascular therapy for large vessel strokes can lead to significantly higher hospital costs without improving outcomes. J Neurointerv Surg 2018; 10(1): 17- 21.
  • 14. Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. New England Journal of Medicine 2013; 368(10): 893-903.
  • 15. Kidwell CS, Jahan R, Gornbein J, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. New England Journal of Medicine 2013; 368(10): 914-923.
  • 16. Ciccone A, Valvassori L, Nichelatti M, et al. Endovascular treatment for acute ischemic stroke. N Engl J Med 2013; 368: 904-913.
  • 17. Qureshi AI, Abd-Allah F, Aleu A, et al. Endovascular treatment for acute ischemic stroke patients: implications and interpretation of IMS III, MR RESCUE, and SYNTHESIS EXPANSION trials: a report from the Working Group of International Congress of Interventional Neurology. Journal of vascular and interventional neurology 2014; 7(1): 56.
  • 18. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015; 372: 11-20.
  • 19. Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. New England Journal of Medicine 2015; 372(11): 1019-1030.
  • 20. Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. New England Journal of Medicine 2015; 372(11): 1009-1018.
  • 21. Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. New England Journal of Medicine 2015; 372(24): 2296-2306.
  • 22. Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. New England Journal of Medicine 2015; 372(24): 2285-2295.
  • 23. Desilles J-P, Loyau S, Syvannarath V, et al. Alteplase reduces downstream microvascular thrombosis and improves the benefit of large artery recanalization in stroke. Stroke 2015; 46(11): 3241-3248.
  • 24. Fischer U, Kaesmacher J, Mendes Pereira V, et al. Direct mechanical thrombectomy versus combined intravenous and mechanical thrombectomy in large-artery anterior circulation stroke: a topical review. Stroke 2017; 48(10): 2912-2918.
  • 25. Flint AC, Avins AL, Eaton A, et al. Risk of distal embolization from tPA (tissue-type plasminogen activator) administration prior to endovascular stroke treatment. Stroke 2020; 51(9): 2697-2704.
  • 26. Khatri P, Yeatts SD, Mazighi M, et al. Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial. The Lancet Neurology 2014; 13(6): 567-574.
  • 27. Nogueira RG, Tsivgoulis G. Large vessel occlusion strokes after the DIRECT-MT and SKIP trials: is the alteplase syringe half empty or half full? Stroke 2020; 51(10): 3182- 3186.
  • 28. Coutinho JM, Liebeskind DS, Slater L-A, et al. Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR studies. JAMA neurology 2017; 74(3): 268-274.
  • 29. Kim CH, Jeon JP, Kim S-E, et al. Endovascular treatment with intravenous thrombolysis versus endovascular treatment alone for acute anterior circulation stroke: a meta-analysis of observational studies. Journal of Korean Neurosurgical Society 2018; 61(4): 467.
  • 30. Yang P, Zhang Y, Zhang L, et al. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. New England Journal of Medicine 2020; 382(21): 1981-1993.
  • 31. Vidale S, Romoli M, Consoli D, et al. Bridging versus direct mechanical thrombectomy in acute ischemic stroke: a subgroup pooled meta-analysis for time of intervention, eligibility, and study design. Cerebrovascular Diseases 2020; 49(2): 223-232.
  • 32. Suzuki K, Matsumaru Y, Takeuchi M, et al. Effect of mechanical thrombectomy without vs with intravenous thrombolysis on functional outcome among patients with acute ischemic stroke: the SKIP randomized clinical trial. JAMA 2021; 325(3): 244-253.
  • 33. Zi W, Qiu Z, Li F, et al. Effect of endovascular treatment alone vs intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke: the DEVT randomized clinical trial. JAMA 2021; 325(3): 234-243.
  • 34. https://eventpilotadmin.com/web/page.php?page=IntHtm l&project=ISC21&id=135
  • 35. https://www.medscape.com/viewarticle/947987#vp_2 36. https://eventpilotadmin.com/web/page.php?page=IntHtm l&project=ISC21&id=398
  • 37. https://www.medscape.com/viewarticle/947774?src=soc tw 210323 mscpedt news mdscp endovasculartreatment&faf=1
  • 38. Campbell BC, Mitchell PJ, Churilov L, et al. Tenecteplase versus alteplase before thrombectomy for ischemic stroke. New England Journal of Medicine 2018; 378(17): 1573- 1582.
APA Uysal kocabaş z, aykaç ö, Acar B (2021). ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. , 1 - 9. 10.5505/tbdhd.2021.25348
Chicago Uysal kocabaş zehra,aykaç özlem,Acar Bilgehan ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. (2021): 1 - 9. 10.5505/tbdhd.2021.25348
MLA Uysal kocabaş zehra,aykaç özlem,Acar Bilgehan ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. , 2021, ss.1 - 9. 10.5505/tbdhd.2021.25348
AMA Uysal kocabaş z,aykaç ö,Acar B ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. . 2021; 1 - 9. 10.5505/tbdhd.2021.25348
Vancouver Uysal kocabaş z,aykaç ö,Acar B ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. . 2021; 1 - 9. 10.5505/tbdhd.2021.25348
IEEE Uysal kocabaş z,aykaç ö,Acar B "ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?." , ss.1 - 9, 2021. 10.5505/tbdhd.2021.25348
ISNAD Uysal kocabaş, zehra vd. "ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?". (2021), 1-9. https://doi.org/10.5505/tbdhd.2021.25348
APA Uysal kocabaş z, aykaç ö, Acar B (2021). ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. Türk Beyin Damar Hastalıkları Dergisi, 27(1), 1 - 9. 10.5505/tbdhd.2021.25348
Chicago Uysal kocabaş zehra,aykaç özlem,Acar Bilgehan ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. Türk Beyin Damar Hastalıkları Dergisi 27, no.1 (2021): 1 - 9. 10.5505/tbdhd.2021.25348
MLA Uysal kocabaş zehra,aykaç özlem,Acar Bilgehan ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. Türk Beyin Damar Hastalıkları Dergisi, vol.27, no.1, 2021, ss.1 - 9. 10.5505/tbdhd.2021.25348
AMA Uysal kocabaş z,aykaç ö,Acar B ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. Türk Beyin Damar Hastalıkları Dergisi. 2021; 27(1): 1 - 9. 10.5505/tbdhd.2021.25348
Vancouver Uysal kocabaş z,aykaç ö,Acar B ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?. Türk Beyin Damar Hastalıkları Dergisi. 2021; 27(1): 1 - 9. 10.5505/tbdhd.2021.25348
IEEE Uysal kocabaş z,aykaç ö,Acar B "ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?." Türk Beyin Damar Hastalıkları Dergisi, 27, ss.1 - 9, 2021. 10.5505/tbdhd.2021.25348
ISNAD Uysal kocabaş, zehra vd. "ENDOVASKÜLER TEDAVİ ÖNCESİNDE TROMBOLİTİK TEDAVİ VERELİM Mİ, VERMEYELİM Mİ?". Türk Beyin Damar Hastalıkları Dergisi 27/1 (2021), 1-9. https://doi.org/10.5505/tbdhd.2021.25348