Beneficial Effects of Urapidil against Renal
Ischemia Reperfusion-Related Renal Injury

TANYELİ, Ayhan; ERASLAN, Ersen; GÜZEL ERDOĞAN, Derya; GÜLER, Mustafa Can; DOĞANAY, Songül; ÇOMAKLI, Selim

doi:10.14744/scie.2022.89421

Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury

Derya Güzel Erdoğan, (Fizyoloji Bölümü, Sakarya Üniversite Tıp Fakültesi, Sakarya, Türkiye)

Ayhan Tanyeli, (Fizyoloji Bölümü, Atatürk Üniversite Tıp Fakültesi, Erzurum, Türkiye)

Mustafa Can Güler, (Fizyoloji Bölümü, Atatürk Üniversite Tıp Fakültesi, Erzurum, Türkiye)

Ersen Eraslan, (Fizyoloji Bölümü, Yozgat Bozok Üniversitesi Tıp, Yozgat, Türkiye)

Selim Çomaklı, (Patoloji Anabilim Dalı, Atatürk Üniversite Veteriner Fakültesi, Erzurum, Türkiye)

Songül Doğanay (Fizyoloji Bölümü, Sakarya Üniversite Tıp Fakültesi, Sakarya, Türkiye)

Southern Clinics of Istanbul Eurasia

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Yıl: 2022 Cilt: 33 Sayı: 2 Sayfa Aralığı: 198 - 202 Metin Dili: İngilizce DOI: 10.14744/scie.2022.89421 İndeks Tarihi: 21-07-2022

Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury

Öz:

Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondial- dehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal dam- age induced by I/R.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜZEL ERDOĞAN D, TANYELİ A, GÜLER M, ERASLAN E, ÇOMAKLI S, DOĞANAY S (2022). Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. , 198 - 202. 10.14744/scie.2022.89421
Chicago	GÜZEL ERDOĞAN Derya,TANYELİ Ayhan,GÜLER Mustafa Can,ERASLAN Ersen,ÇOMAKLI Selim,DOĞANAY Songül Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. (2022): 198 - 202. 10.14744/scie.2022.89421
MLA	GÜZEL ERDOĞAN Derya,TANYELİ Ayhan,GÜLER Mustafa Can,ERASLAN Ersen,ÇOMAKLI Selim,DOĞANAY Songül Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. , 2022, ss.198 - 202. 10.14744/scie.2022.89421
AMA	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. . 2022; 198 - 202. 10.14744/scie.2022.89421
Vancouver	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. . 2022; 198 - 202. 10.14744/scie.2022.89421
IEEE	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S "Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury." , ss.198 - 202, 2022. 10.14744/scie.2022.89421
ISNAD	GÜZEL ERDOĞAN, Derya vd. "Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury". (2022), 198-202. https://doi.org/10.14744/scie.2022.89421

APA	GÜZEL ERDOĞAN D, TANYELİ A, GÜLER M, ERASLAN E, ÇOMAKLI S, DOĞANAY S (2022). Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. Southern Clinics of Istanbul Eurasia, 33(2), 198 - 202. 10.14744/scie.2022.89421
Chicago	GÜZEL ERDOĞAN Derya,TANYELİ Ayhan,GÜLER Mustafa Can,ERASLAN Ersen,ÇOMAKLI Selim,DOĞANAY Songül Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. Southern Clinics of Istanbul Eurasia 33, no.2 (2022): 198 - 202. 10.14744/scie.2022.89421
MLA	GÜZEL ERDOĞAN Derya,TANYELİ Ayhan,GÜLER Mustafa Can,ERASLAN Ersen,ÇOMAKLI Selim,DOĞANAY Songül Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. Southern Clinics of Istanbul Eurasia, vol.33, no.2, 2022, ss.198 - 202. 10.14744/scie.2022.89421
AMA	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. Southern Clinics of Istanbul Eurasia. 2022; 33(2): 198 - 202. 10.14744/scie.2022.89421
Vancouver	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury. Southern Clinics of Istanbul Eurasia. 2022; 33(2): 198 - 202. 10.14744/scie.2022.89421
IEEE	GÜZEL ERDOĞAN D,TANYELİ A,GÜLER M,ERASLAN E,ÇOMAKLI S,DOĞANAY S "Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury." Southern Clinics of Istanbul Eurasia, 33, ss.198 - 202, 2022. 10.14744/scie.2022.89421
ISNAD	GÜZEL ERDOĞAN, Derya vd. "Beneficial Effects of Urapidil against Renal Ischemia Reperfusion-Related Renal Injury". Southern Clinics of Istanbul Eurasia 33/2 (2022), 198-202. https://doi.org/10.14744/scie.2022.89421