TY  - JOUR
TI  - Beneficial Effects of Urapidil against Renal
Ischemia Reperfusion-Related Renal Injury
AB  - Objective: The potential protective effects of urapidil (Ura) against renal injury composed
by ischemia reperfusion (I/R) were examined.
Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and
I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total
oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondial-
dehyde (MDA) parameters were determined.
Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in
the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of
interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined
due to Ura administration.
Conclusion: The results of the study showed that Ura is highly effective against renal dam-
age induced by I/R.
AU  - TANYELİ, Ayhan
AU  - ERASLAN, Ersen
AU  - GÜZEL ERDOĞAN, Derya
AU  - GÜLER, Mustafa Can
AU  - DOĞANAY, Songül
AU  - ÇOMAKLI, Selim
DO  - 10.14744/scie.2022.89421
PY  - 2022
JO  - Southern Clinics of Istanbul Eurasia
VL  - 33
IS  - 2
SN  - 2587-0998
SP  - 198
EP  - 202
DB  - TRDizin
UR  - http://search/yayin/detay/535432
ER  -