ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE

Çubuk, Can; ALTIPARMAK, TAYLAN; çubuk, hazal

doi:10.5505/tbdhd.2022.27879

ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE

Taylan ALTIPARMAK, (Çankırı Devlet Hastanesi, Nöroloji Kliniği, Çankırı, Türkiye)

Can ÇUBUK, (Çankırı Devlet Hastanesi, Nöroloji Kliniği, Çankırı, Türkiye)

Hazal SELVİ ÇUBUK (Çankırı Devlet Hastanesi, Radyoloji Kliniği, Çankırı, Türkiye)

Türk Beyin Damar Hastalıkları Dergisi

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Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 23 - 30 Metin Dili: İngilizce DOI: 10.5505/tbdhd.2022.27879 İndeks Tarihi: 21-07-2022

ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE

Öz:

INTRODUCTION: The clinical presentation of COVID-19 varies greatly. Even though, disease cause predominantly respiratory manifestations, because of the inflammatory nature of the disease, it also triggers thromboembolic conditions. We aim to describe the features of COVID-19 positive ischemic stroke patients of 1-year experiences of a single center. METHODS: A total of 258 patients, diagnosed with ischemic cerebrovascular disease (25 patients of with strokes had respiratory symptoms at initial presentation and COVID-19 diagnosis), were evaluated retrospectively during the study period. RESULTS: A majority of these patients strokes were in anterior circulation territory and most of them were large vessel occlusion. Eighteen of the patients had positive COVID-19 RT-PCR results, while 7 of the patients had negative results but their thorax CTs made the diagnosis of COVID-19. Hypertension (56%), diabetes (44%), and atrial fibrillation (44%) were the most comorbidities. Thirteen patients stroke etiology was cardioembolism, 9 had atherosclerosis. Fourteen of the patients NIHSS were >10, and 13 of them died. Patients with high levels of CRP (13/25), D-Dimer (15/25) and Ferritin (14/25) had mRS>3 at admission. Most of the patients (19/25) had CO-RADS 5 scores at admission. Two patients had mRS 4-5, 9 patients had mRS 0-3 at the discharge period. Fourteen patients died at the hospital period. DISCUSSION AND CONCLUSION: The admission NIHSS scores determined significantly the prognosis. Moreover, higher age, women gender, LVO in neuroimagining, high CRP, Ferritin, D-dimer levels, COVID-19 RT-PCR positivity, presence of hypertension and atrial fibrillation comorbidities showed poor outcome.

Anahtar Kelime:

COVİD-19 HASTALARINDA İSKEMİK İNME: TEK MERKEZİN BİR YILLIK TECRÜBESİ

Öz:

GİRİŞ ve AMAÇ: COVİD-19’un klinik özellikleri değişkenlik göstermektedir. Hastalık sıklıkla solunum sistemi semptomları ile prezente olmakla birlikte hastalığın inflamatuar doğası sonucu tromboembolik olaylar da tetiklenebilmektedir. Çalışmamızda bir yıl içerisinde merkezimizde tanı alan ve COVİD-19 ile birliktelik gösteren iskemik inme hastalarının klinik özelliklerini tanımlamayı amaçladık. YÖNTEM ve GEREÇLER: Kliniğimizde bir yıl boyunca iskemik serebrovasküler hastalık tanısı konulan toplam 258 hasta geriye dönük olarak tarandı. Bu hastaların klinik, laboratuar ve görüntüleme bulguları retrospektif olarak değerlendirildi. Toplam 25 hasta COVİD-19 tanısı almış olup, çalışmaya dahil edilmiştir. BULGULAR: Hastalardan 18'inin COVID-19 RT-PCR sonucu pozitif olarak, 7'sinin ise negatif olmasına rağmen toraks BT'lerinde tipik COVID-19 pnömoni bulguları olması nedeniyle klinik ve radyolojik olarak tanı konulmuştur. Hastaların çoğunluğunda anterior dolaşımda, geniş damar oklüzyonu sonucu enfarkt oluşumu gözlenmiştir. En sık eşlik eden hastalıklar hipertansiyon (%56), diyabet (%44) ve atriyal fibrilasyon (%44) olarak belirlenmiştir. On üç hastada kardiyoembolizm, 9 hastadaysa ateroskleroz inme etyolojisi olarak tespit edilmiştir. NIHSS skoru 10’un üzerinde olan 14 hastadan 13’ü mortal seyretmiştir. CRP (13/25), D-Dimer (15/25) ve Ferritin (14/25) düzeyleri yüksek olan hastalarda mRS>3 bulunmuştur. Hastaların çoğunda (19/25) Toraks BT görüntüleme bulgusu CORADS 5 olarak değerlendirilmiştir. Taburculuk döneminde iki hastada mRS 4-5, 9 hastada mRS 0-3 şeklindedir. Toplamda 14 hasta ise mortal seyretmiştir. TARTIŞMA ve SONUÇ: Prognozu belirlemede önemli parametrelerden biri ilk değerlendirmedeki NIHSS skorları olduğu düşünülmektedir. Ayrıca, ileri yaş, kadın cinsiyet, beyin görüntülemede geniş damar oklüzyonu varlığı, yüksek CRP, Ferritin, D-dimer seviyeleri, COVID-19 RT-PCR pozitifliği, hipertansiyon ve atriyal fibrilasyon komorbiditeleri olan hastaların prognozu kötü seyretmiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALTIPARMAK T, Çubuk C, çubuk h (2022). ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. , 23 - 30. 10.5505/tbdhd.2022.27879
Chicago	ALTIPARMAK TAYLAN,Çubuk Can,çubuk hazal ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. (2022): 23 - 30. 10.5505/tbdhd.2022.27879
MLA	ALTIPARMAK TAYLAN,Çubuk Can,çubuk hazal ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. , 2022, ss.23 - 30. 10.5505/tbdhd.2022.27879
AMA	ALTIPARMAK T,Çubuk C,çubuk h ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. . 2022; 23 - 30. 10.5505/tbdhd.2022.27879
Vancouver	ALTIPARMAK T,Çubuk C,çubuk h ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. . 2022; 23 - 30. 10.5505/tbdhd.2022.27879
IEEE	ALTIPARMAK T,Çubuk C,çubuk h "ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE." , ss.23 - 30, 2022. 10.5505/tbdhd.2022.27879
ISNAD	ALTIPARMAK, TAYLAN vd. "ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE". (2022), 23-30. https://doi.org/10.5505/tbdhd.2022.27879

APA	ALTIPARMAK T, Çubuk C, çubuk h (2022). ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi, 28(1), 23 - 30. 10.5505/tbdhd.2022.27879
Chicago	ALTIPARMAK TAYLAN,Çubuk Can,çubuk hazal ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi 28, no.1 (2022): 23 - 30. 10.5505/tbdhd.2022.27879
MLA	ALTIPARMAK TAYLAN,Çubuk Can,çubuk hazal ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi, vol.28, no.1, 2022, ss.23 - 30. 10.5505/tbdhd.2022.27879
AMA	ALTIPARMAK T,Çubuk C,çubuk h ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi. 2022; 28(1): 23 - 30. 10.5505/tbdhd.2022.27879
Vancouver	ALTIPARMAK T,Çubuk C,çubuk h ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi. 2022; 28(1): 23 - 30. 10.5505/tbdhd.2022.27879
IEEE	ALTIPARMAK T,Çubuk C,çubuk h "ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE." Türk Beyin Damar Hastalıkları Dergisi, 28, ss.23 - 30, 2022. 10.5505/tbdhd.2022.27879
ISNAD	ALTIPARMAK, TAYLAN vd. "ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE". Türk Beyin Damar Hastalıkları Dergisi 28/1 (2022), 23-30. https://doi.org/10.5505/tbdhd.2022.27879