Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 31 - 37 Metin Dili: İngilizce DOI: 10.5505/tbdhd.2022.04880 İndeks Tarihi: 21-07-2022

THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS

Öz:
INTRODUCTION: This study aimed to assess the diagnostic and prognostic value of red cell distribution width (RDW) which is an easily accesible parameter obtained from complete blood count in patients with cerebral venous thrombosis (CVT) in a single tertiary center. METHODS: Medical records of 69 patients with cerebral venous thrombosis who were followed in our clinic were reviewed. Demographic characteristics, biochemical parameters, hemogram parameters, localization of the affected venous structures, admission NIHSS scores and mRS scores at discharge were recorded. Demographic characteristics and hemogram values of 60 age-sex matched healthy adults were also recorded. RESULTS: RDW was demonstrated to be significantly higher in patient group (14.58± 2.33) when compared to controls (12.99± 0.76) (p<0.001*). Besides, mean hemoglobin and hematocrit values of patients were found to be lower than controls (p<0.05). In ROC curve analysis, an RDW value of >13.11% was found to have a sensitivity of 73.9% and specificity of 61.7% for diagnosis of CVT (AUC: 0.746 95% CI: 0.662-0.829, p<0.001). RDW demonstrated a significant positive correlation with mRS scores whilst no correlation was detected regarding NIHSS scores. DISCUSSION AND CONCLUSION: This study demonstrates an independent association between RDW and presence of CVT. RDW is a simple and easily accessible marker obtained from routine hemogram examinations and our results support its use for diagnostic, as well as prognostic purposes in CVT patients.
Anahtar Kelime:

SEREBRAL VENÖZ TROMBOZLARDA, ERİTROSİT DAĞILIM GENİŞLİĞİNİN (RDW) TANISAL VE PROGNOSTİK DEĞERİ

Öz:
GİRİŞ ve AMAÇ: Bu çalışmada, üçüncü basamak bir merkezde serebral venöz tromboz (SVT) olan hastalarda tam kan sayımından elde edilen kolay erişilebilir bir parametre olan eritrosit dağılım genişliğinin (RDW) tanısal ve prognostik değerinin değerlendirilmesi amaçlandı. YÖNTEM ve GEREÇLER: Kliniğimizde takip edilen serebral ven trombozu olan 69 hastanın tıbbi kayıtları incelendi. Demografik özellikler, biyokimyasal parametreler, hemogram parametreleri, etkilenen venöz yapıların lokalizasyonu, başvuru NIHSS skorları ve taburculuk mRS skorları kaydedildi. Ayrıca 60 yaş-cinsiyet uyumlu sağlıklı yetişkinin demografik özellikleri ve hemogram değerleri kaydedildi. BULGULAR: RDW'nin hasta grubunda (14,58±2,33) kontrollere (12,99±0,76) göre anlamlı derecede yüksek olduğu gösterildi (p<0,001*). Ayrıca hastaların ortalama hemoglobin ve hematokrit değerleri kontrollere göre daha düşük bulundu (p<0.05). ROC eğrisi analizinde, >%13,11'lik bir RDW değerinin, SVT tanısı için %73.9 duyarlılık ve %61.7 özgüllüğe sahip olduğu bulundu (AUC: 0.746 %95 CI: 0.662-0.829, p<0.001). RDW, mRS puanları ile anlamlı bir pozitif korelasyon gösterirken, NIHSS puanları ile ilgili herhangi bir korelasyon tespit edilmedi. TARTIŞMA ve SONUÇ: Bu çalışma, RDW ile SVT varlığı arasında bağımsız bir ilişki olduğunu göstermektedir. RDW, rutin hemogram incelemelerinden elde edilen basit ve kolay erişilebilir bir belirteçtir ve sonuçlarımız, SVT hastalarında tanısal ve prognostik amaçlar için kullanımını desteklemektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Batur Caglayan H, Akyol A, Mutlucan H, Arslan İ, Kaya Z, UCAR M, Nazliel B (2022). THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. , 31 - 37. 10.5505/tbdhd.2022.04880
Chicago Batur Caglayan Hale,Akyol Asli,Mutlucan Havva meltem,Arslan İlker,Kaya Zuhre,UCAR MURAT,Nazliel Bijen THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. (2022): 31 - 37. 10.5505/tbdhd.2022.04880
MLA Batur Caglayan Hale,Akyol Asli,Mutlucan Havva meltem,Arslan İlker,Kaya Zuhre,UCAR MURAT,Nazliel Bijen THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. , 2022, ss.31 - 37. 10.5505/tbdhd.2022.04880
AMA Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. . 2022; 31 - 37. 10.5505/tbdhd.2022.04880
Vancouver Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. . 2022; 31 - 37. 10.5505/tbdhd.2022.04880
IEEE Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B "THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS." , ss.31 - 37, 2022. 10.5505/tbdhd.2022.04880
ISNAD Batur Caglayan, Hale vd. "THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS". (2022), 31-37. https://doi.org/10.5505/tbdhd.2022.04880
APA Batur Caglayan H, Akyol A, Mutlucan H, Arslan İ, Kaya Z, UCAR M, Nazliel B (2022). THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. Türk Beyin Damar Hastalıkları Dergisi, 28(1), 31 - 37. 10.5505/tbdhd.2022.04880
Chicago Batur Caglayan Hale,Akyol Asli,Mutlucan Havva meltem,Arslan İlker,Kaya Zuhre,UCAR MURAT,Nazliel Bijen THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. Türk Beyin Damar Hastalıkları Dergisi 28, no.1 (2022): 31 - 37. 10.5505/tbdhd.2022.04880
MLA Batur Caglayan Hale,Akyol Asli,Mutlucan Havva meltem,Arslan İlker,Kaya Zuhre,UCAR MURAT,Nazliel Bijen THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. Türk Beyin Damar Hastalıkları Dergisi, vol.28, no.1, 2022, ss.31 - 37. 10.5505/tbdhd.2022.04880
AMA Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. Türk Beyin Damar Hastalıkları Dergisi. 2022; 28(1): 31 - 37. 10.5505/tbdhd.2022.04880
Vancouver Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS. Türk Beyin Damar Hastalıkları Dergisi. 2022; 28(1): 31 - 37. 10.5505/tbdhd.2022.04880
IEEE Batur Caglayan H,Akyol A,Mutlucan H,Arslan İ,Kaya Z,UCAR M,Nazliel B "THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS." Türk Beyin Damar Hastalıkları Dergisi, 28, ss.31 - 37, 2022. 10.5505/tbdhd.2022.04880
ISNAD Batur Caglayan, Hale vd. "THE DIAGNOSTIC AND PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH (RDW) IN CEREBRAL VENOUS THROMBOSIS". Türk Beyin Damar Hastalıkları Dergisi 28/1 (2022), 31-37. https://doi.org/10.5505/tbdhd.2022.04880