The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19

Background/aim: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, and prostaglandin F2α (PGF2α) levels were determined. Results: Compared with the healthy control group, TWEAK, LTE4, and PGF2α levels were higher in the group of SARS-CoV-2 infection without lung involvement. In the group of SARS-CoV-2 infection with lung involvement, age, fibrinogen, sedimentation, C-reactive protein and ferritin, TWEAK, LTE4, and PGF2α levels were higher, and lymphocyte levels were lower compared with the asymptomatic group. Conclusions: In the study, TWEAK and LTE4 levels increased in cases with COVID-19. These results support that TWEAK/Fn14 pathway and LT may involved in the pathology of aberrant immune response against SARS-CoV-2. Inhibition of each of these pathways may be a potential target in the treatment of COVID-19.

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APA	Yalcin Kehribar D, cihangiroğlu m, Sehmen E, AVCI B, çapraz m, BORAN M, Günaydın C, Ozgen M (2020). The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. , 1786 - 1791. 10.3906/sag-2006-96
Chicago	Yalcin Kehribar Demet,cihangiroğlu mustafa,Sehmen Emine,AVCI BAHATTIN,çapraz mustafa,BORAN MARUF,Günaydın Caner,Ozgen Metin The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. (2020): 1786 - 1791. 10.3906/sag-2006-96
MLA	Yalcin Kehribar Demet,cihangiroğlu mustafa,Sehmen Emine,AVCI BAHATTIN,çapraz mustafa,BORAN MARUF,Günaydın Caner,Ozgen Metin The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. , 2020, ss.1786 - 1791. 10.3906/sag-2006-96
AMA	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. . 2020; 1786 - 1791. 10.3906/sag-2006-96
Vancouver	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. . 2020; 1786 - 1791. 10.3906/sag-2006-96
IEEE	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M "The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19." , ss.1786 - 1791, 2020. 10.3906/sag-2006-96
ISNAD	Yalcin Kehribar, Demet vd. "The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19". (2020), 1786-1791. https://doi.org/10.3906/sag-2006-96

APA	Yalcin Kehribar D, cihangiroğlu m, Sehmen E, AVCI B, çapraz m, BORAN M, Günaydın C, Ozgen M (2020). The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. Turkish Journal of Medical Sciences, 50(8), 1786 - 1791. 10.3906/sag-2006-96
Chicago	Yalcin Kehribar Demet,cihangiroğlu mustafa,Sehmen Emine,AVCI BAHATTIN,çapraz mustafa,BORAN MARUF,Günaydın Caner,Ozgen Metin The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. Turkish Journal of Medical Sciences 50, no.8 (2020): 1786 - 1791. 10.3906/sag-2006-96
MLA	Yalcin Kehribar Demet,cihangiroğlu mustafa,Sehmen Emine,AVCI BAHATTIN,çapraz mustafa,BORAN MARUF,Günaydın Caner,Ozgen Metin The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. Turkish Journal of Medical Sciences, vol.50, no.8, 2020, ss.1786 - 1791. 10.3906/sag-2006-96
AMA	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. Turkish Journal of Medical Sciences. 2020; 50(8): 1786 - 1791. 10.3906/sag-2006-96
Vancouver	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19. Turkish Journal of Medical Sciences. 2020; 50(8): 1786 - 1791. 10.3906/sag-2006-96
IEEE	Yalcin Kehribar D,cihangiroğlu m,Sehmen E,AVCI B,çapraz m,BORAN M,Günaydın C,Ozgen M "The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19." Turkish Journal of Medical Sciences, 50, ss.1786 - 1791, 2020. 10.3906/sag-2006-96
ISNAD	Yalcin Kehribar, Demet vd. "The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19". Turkish Journal of Medical Sciences 50/8 (2020), 1786-1791. https://doi.org/10.3906/sag-2006-96