TY  - JOUR
TI  - The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19
AB  - Background/aim: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the
morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis
factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Materials and methods: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with
COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4,
and prostaglandin F2α (PGF2α) levels were determined.
Results: Compared with the healthy control group, TWEAK, LTE4, and PGF2α levels were higher in the group of SARS-CoV-2 infection
without lung involvement. In the group of SARS-CoV-2 infection with lung involvement, age, fibrinogen, sedimentation, C-reactive
protein and ferritin, TWEAK, LTE4, and PGF2α levels were higher, and lymphocyte levels were lower compared with the asymptomatic
group.
Conclusions: In the study, TWEAK and LTE4 levels increased in cases with COVID-19. These results support that TWEAK/Fn14
pathway and LT may involved in the pathology of aberrant immune response against SARS-CoV-2. Inhibition of each of these pathways
may be a potential target in the treatment of COVID-19.
AU  - cihangiroğlu, mustafa
AU  - çapraz, mustafa
AU  - BORAN, MARUF
AU  - Günaydın, Caner
AU  - Yalcin Kehribar, Demet
AU  - AVCI, BAHATTIN
AU  - Sehmen, Emine
AU  - Ozgen, Metin
DO  - 10.3906/sag-2006-96
PY  - 2020
JO  - Turkish Journal of Medical Sciences
VL  - 50
IS  - 8
SN  - 1300-0144
SP  - 1786
EP  - 1791
DB  - TRDizin
UR  - http://search/yayin/detay/535612
ER  -