TY  - JOUR
TI  - Investigation of the Protective Effects of Dexpanthenol and 
Boldine in Cisplatin-Induced Experimental Testis Injury 
Model in Rats
AB  - This study was carried out to determine the protective effects of dexpanthenol and boldin against 
possible testicular damage caused by cisplatin. 48 Male Wistar rats (250-270 g) aged 4-5 months 
were used in the study. 8 groups were formed with 6 animals in each group. Boldin (20 and 40
mg/kg) and dexpentanol (250 and 500 mg/kg) were administered to rats along with cisplatin (7 
mg/kg). At the end of the 14th day, spermatogenic and histopathological examinations and 
testicular tissue malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase 
(GSH-Px) and catalase (CAT) levels were determined. A significant decrease in sperm quality and 
motility, a significant increase in MDA, and a significant decrease in SOD, GSH-Px, and CAT levels 
were observed in the cisplatin group. MDA levels were significantly lower in the other groups 
compared to the cisplatin group. SOD, GSH-Px and CAT enzyme levels increased in the treatment 
groups compared to the cisplatin group and approached the control group. Combined application of 
high doses of both substances with cisplatin reduced histopathological lesions. Significant 
increases were found in the groups in which both doses of dexpanthenol and boldin were 
combined with cisplatin compared to the cisplatin group. As a result, it was concluded that 
dexpanthenol and boldin treatments may have a protective effect against cisplatin-induced 
testicular damage in rats.
AU  - ŞAHİN, MAHMUT
AU  - KARA, Haki
AU  - KUMRU, Alper Serhat
AU  - GUNGOR, HUSEYIN
AU  - tuna, zeynep
PY  - 2022
JO  - Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
VL  - 36
IS  - 2
SN  - 1308-9323
SP  - 101
EP  - 107
DB  - TRDizin
UR  - http://search/yayin/detay/535894
ER  -