TY  - JOUR
TI  - Pectin/poly(vinylpyrrolidone) composite sponges as
wound dressings for delivery of silver sulfadiazine
AB  - Wound dressings based on sponges with good antimicrobial performance could be suitable options to
prevent wound infection and promote wound healing for exudative wounds. In the current study, silver sulfadiazine
(AgSD) loaded ionically crosslinked pectin (PEC)/ polyvinylpyrrolidone (PVP) based composite sponges were
fabricated by freeze-dried molding with tunable mechanical features for wound dressing application. The structure of
composite sponges was confirmed by Fourier transform infrared spectroscopy (FT-IR) and they were characterized in
terms of gel fraction, mechanical, swelling, degradation and drug release properties. In particular, the longer incubation
of composite sponges in CaCl2 solution resulted in enhanced mechanical properties. For instance, compressive moduli
of PEC sponges were improved from 23.30 kPa to 37.24 kPa after 30 minutes and 120 minutes incubation in CaCl2
solution, respectively. Moreover, the addition of PVP improved the mechanical property of pectin. All composite
sponges exhibited higher gel fraction in distilled water compared to phosphate buffer saline (PBS, pH: 7.4).
The composite sponges exhibited rapid and high swelling ability of 802.47±69.31% and 714.56±39.78% for PEC and
PEC/PVP composite sponges, respectively. They degraded completely after 48 hours. AgSD entrapment efficiency was
about 70% for all composite sponges. The AgSD release from PEC slightly reduced after blending PVP, and the
cumulative release was 39.19% and 51.49% after 1 h, respectively. AgSD/PEC and AgSD/PEC/PVP composite
sponges allowed AgSD release for six hours. In summary, AgSD/PEC/PVP composite sponges with antimicrobial
activity have a favorable potential to accelerate wound healing by providing wound closure and effectively absorbing
wound exudates.
AU  - ALARÇİN, Emine
DO  - 10.29228/jrp.188
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 4
SN  - 2630-6344
SP  - 900
EP  - 910
DB  - TRDizin
UR  - http://search/yayin/detay/535926
ER  -