TY  - JOUR
TI  - Synthesis, structure elucidation and cytotoxic activities of
2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3-
thione derivatives
AB  - In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were
synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted
thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data
obtained from elemental analysis, HPLC, UV, IR, 1H-NMR and MS spectra. All of the compounds were tested for their
cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a,
1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 μg/mL and 10.0 μg/mL) in L929 cell lines.
Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and
9a-c showed decreased growth inhibition on L929 cell lines
AU  - AKBUĞA, Julide
AU  - KARAKUŞ, Sevgi
AU  - KANDEMİR, Levent
AU  - Rollas, Sevim
AU  - ÖZBAŞ, Suna
DO  - 10.29228/jrp.192
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 4
SN  - 2630-6344
SP  - 941
EP  - 953
DB  - TRDizin
UR  - http://search/yayin/detay/535934
ER  -