TY  - JOUR
TI  - Assessment of drug-related problems in pediatric
inpatients by clinical pharmacist-led medication review:
An observational study
AB  - It is well-known that problems related to pharmacotherapy affect pediatric patients' therapy outcomes.
Evaluating pharmacotherapy by a clinical pharmacist in pediatric clinics could ameliorate drug-related problems
(DRPs). This study aimed to identify and compare the prevalence and types of DRPs in pediatric patients in two study
phases: the prospective phase while providing clinical pharmacist-led medication review service and the retrospective
phase among subjects obtained by age-sex-diagnose–matching according to the prospective phase. This observational
study consisted of two phases (the prospective part between June 2019 and February 2020 and the retrospective part
between December 2018 and February 2019) and was conducted in a pediatric unit of a university hospital. Turkish
version of Pharmaceutical Care Network Europe Foundation Classification V9.1 is used to identify DRPs. Lexicomp®
and Micromedex® were the resources used to assess the potential drug-drug interactions. Medscape® and UpToDate®
recommendations and evidence-based guidelines were applied in assessing compliance with approved
pharmacotherapy of patients. Prevalence and types of DRPs and clinical pharmacist interventions were assessed.
Among 174 patients, at least one DRP was seen in 78,16% of the patients, and 527 DRPs were identified. Some of the
problems were related to drug-drug interaction (64,90%), therapeutic monitoring (11,39%), and dosing (11,01%). Antiinfectives,
bronchodilators, and inhaled corticosteroids were the most frequently used drugs. There were significant
differences in duration of hospitalization (p=0,025), number of drugs used (p=0,003), and total DRPs (p=0,019) between
the study and control groups. The findings demonstrate the potential to detect DRPs through pharmacist involvement
in direct patient care.
AU  - Nuhoglu, Cagatay
AU  - OKUYAN, Betul
AU  - SANCAR, MESUT
AU  - ŞAHİN, Yeliz
DO  - 10.29228/jrp.198
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 4
SN  - 2630-6344
SP  - 1007
EP  - 1015
DB  - TRDizin
UR  - http://search/yayin/detay/535945
ER  -