Colchicine intolerance in FMF patients and primary obstacles for optimal dosing

Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation. Materials and methods: All patients were recruited from “FMF in Central Anatolia” (FiCA) cohort, 915 adults with a minimum followup time of 6 months during which they had obeyed all treatment instructions. Demographic and anthropometric data, FMF disease characteristics, disease severity, complications, and treatment features were recorded on a web-based registry. Prevalence of colchicine intolerance and characteristics of intolerant patients were analyzed. Results: Effective colchicine doses cannot be maintained in 172 (18.7%) subjects. Main side effects that limit optimal dosing were as follows: diarrhea in 99 (10.8%), elevation in transaminases in 54 (5.9%), leukopenia in 10 (%1.1), renal impairment in 14 (1.3%), myopathy in five (0.5%), and allergic skin reaction in two. Colchicine had to be permanently ceased in 18 (2%) patients because of serious toxicity. Male sex and obesity were found to be associated with liver toxicity, and having a normal body weight was associated with diarrhea. Chronic inflammation and proteinuria were more common in colchicine-intolerant patients, and they had reported more frequent attacks compared to those tolerating optimal doses. Conclusion: Colchicine intolerance is an important problem in daily clinical practice, mainly due to diarrhea and liver toxicity. Suboptimal colchicine dosing is associated with complications.

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Satış H, Armagan B, BODAKÇİ E, Atas N, SARI A, Yasar Bilge N, Yapar D, Bilici Salman R, Yardimci G, Babaoglu H, Kılıç L, Goker B, HAZNEDAROGLU S, KASIFOGLU T, Kalyoncu U, TUFAN A (2020). Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. , 1337 - 1343. 10.3906/sag-2001-261
Chicago	Satış Hasan,Armagan Berkan,BODAKÇİ ERDAL,Atas Nuh,SARI ALPER,Yasar Bilge Nazife Sule,Yapar Dilek,Bilici Salman Reyhan,Yardimci Gozde Kubra,Babaoglu Hakan,Kılıç Levent,Goker Berna,HAZNEDAROGLU SEMINUR,KASIFOGLU TIMUCIN,Kalyoncu Umut,TUFAN ABDURRAHMAN Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. (2020): 1337 - 1343. 10.3906/sag-2001-261
MLA	Satış Hasan,Armagan Berkan,BODAKÇİ ERDAL,Atas Nuh,SARI ALPER,Yasar Bilge Nazife Sule,Yapar Dilek,Bilici Salman Reyhan,Yardimci Gozde Kubra,Babaoglu Hakan,Kılıç Levent,Goker Berna,HAZNEDAROGLU SEMINUR,KASIFOGLU TIMUCIN,Kalyoncu Umut,TUFAN ABDURRAHMAN Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. , 2020, ss.1337 - 1343. 10.3906/sag-2001-261
AMA	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. . 2020; 1337 - 1343. 10.3906/sag-2001-261
Vancouver	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. . 2020; 1337 - 1343. 10.3906/sag-2001-261
IEEE	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A "Colchicine intolerance in FMF patients and primary obstacles for optimal dosing." , ss.1337 - 1343, 2020. 10.3906/sag-2001-261
ISNAD	Satış, Hasan vd. "Colchicine intolerance in FMF patients and primary obstacles for optimal dosing". (2020), 1337-1343. https://doi.org/10.3906/sag-2001-261

APA	Satış H, Armagan B, BODAKÇİ E, Atas N, SARI A, Yasar Bilge N, Yapar D, Bilici Salman R, Yardimci G, Babaoglu H, Kılıç L, Goker B, HAZNEDAROGLU S, KASIFOGLU T, Kalyoncu U, TUFAN A (2020). Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turkish Journal of Medical Sciences, 50(5), 1337 - 1343. 10.3906/sag-2001-261
Chicago	Satış Hasan,Armagan Berkan,BODAKÇİ ERDAL,Atas Nuh,SARI ALPER,Yasar Bilge Nazife Sule,Yapar Dilek,Bilici Salman Reyhan,Yardimci Gozde Kubra,Babaoglu Hakan,Kılıç Levent,Goker Berna,HAZNEDAROGLU SEMINUR,KASIFOGLU TIMUCIN,Kalyoncu Umut,TUFAN ABDURRAHMAN Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turkish Journal of Medical Sciences 50, no.5 (2020): 1337 - 1343. 10.3906/sag-2001-261
MLA	Satış Hasan,Armagan Berkan,BODAKÇİ ERDAL,Atas Nuh,SARI ALPER,Yasar Bilge Nazife Sule,Yapar Dilek,Bilici Salman Reyhan,Yardimci Gozde Kubra,Babaoglu Hakan,Kılıç Levent,Goker Berna,HAZNEDAROGLU SEMINUR,KASIFOGLU TIMUCIN,Kalyoncu Umut,TUFAN ABDURRAHMAN Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turkish Journal of Medical Sciences, vol.50, no.5, 2020, ss.1337 - 1343. 10.3906/sag-2001-261
AMA	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turkish Journal of Medical Sciences. 2020; 50(5): 1337 - 1343. 10.3906/sag-2001-261
Vancouver	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turkish Journal of Medical Sciences. 2020; 50(5): 1337 - 1343. 10.3906/sag-2001-261
IEEE	Satış H,Armagan B,BODAKÇİ E,Atas N,SARI A,Yasar Bilge N,Yapar D,Bilici Salman R,Yardimci G,Babaoglu H,Kılıç L,Goker B,HAZNEDAROGLU S,KASIFOGLU T,Kalyoncu U,TUFAN A "Colchicine intolerance in FMF patients and primary obstacles for optimal dosing." Turkish Journal of Medical Sciences, 50, ss.1337 - 1343, 2020. 10.3906/sag-2001-261
ISNAD	Satış, Hasan vd. "Colchicine intolerance in FMF patients and primary obstacles for optimal dosing". Turkish Journal of Medical Sciences 50/5 (2020), 1337-1343. https://doi.org/10.3906/sag-2001-261