TY  - JOUR
TI  - Colchicine intolerance in FMF patients and primary obstacles for optimal dosing
AB  - Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective
colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk
factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.
Materials and methods: All patients were recruited from “FMF in Central Anatolia” (FiCA) cohort, 915 adults with a minimum followup time of 6 months during which they had obeyed all treatment instructions. Demographic and anthropometric data, FMF disease
characteristics, disease severity, complications, and treatment features were recorded on a web-based registry. Prevalence of colchicine
intolerance and characteristics of intolerant patients were analyzed.
Results: Effective colchicine doses cannot be maintained in 172 (18.7%) subjects. Main side effects that limit optimal dosing were
as follows: diarrhea in 99 (10.8%), elevation in transaminases in 54 (5.9%), leukopenia in 10 (%1.1), renal impairment in 14 (1.3%),
myopathy in five (0.5%), and allergic skin reaction in two. Colchicine had to be permanently ceased in 18 (2%) patients because of
serious toxicity. Male sex and obesity were found to be associated with liver toxicity, and having a normal body weight was associated
with diarrhea. Chronic inflammation and proteinuria were more common in colchicine-intolerant patients, and they had reported more
frequent attacks compared to those tolerating optimal doses.
Conclusion: Colchicine intolerance is an important problem in daily clinical practice, mainly due to diarrhea and liver toxicity.
Suboptimal colchicine dosing is associated with complications.
AU  - Yapar, Dilek
AU  - Atas, Nuh
AU  - Goker, Berna
AU  - Bilici Salman, Reyhan
AU  - Armagan, Berkan
AU  - SARI, ALPER
AU  - Kalyoncu, Umut
AU  - Kılıç, Levent
AU  - BODAKÇİ, ERDAL
AU  - KASIFOGLU, TIMUCIN
AU  - HAZNEDAROGLU, SEMINUR
AU  - Yasar Bilge, Nazife Sule
AU  - Babaoglu, Hakan
AU  - Yardimci, Gozde Kubra
AU  - Satış, Hasan
AU  - TUFAN, ABDURRAHMAN
DO  - 10.3906/sag-2001-261
PY  - 2020
JO  - Turkish Journal of Medical Sciences
VL  - 50
IS  - 5
SN  - 1300-0144
SP  - 1337
EP  - 1343
DB  - TRDizin
UR  - http://search/yayin/detay/535968
ER  -