TY  - JOUR
TI  - Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing
in rats: an experimental model
AB  - Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound
healing.
Materials and methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long
midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision
was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and
rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program.
P < 0.05 was considered significant.
Results: The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3,
respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between
Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the
difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was
observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score,
mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score
were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003).
Conclusion: ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are
required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.
AU  - ariturk, mehmet ender
AU  - Demirel, Berat Dilek
AU  - Bıçakcı, Unal
AU  - Arıtürk, Nurşen
AU  - Gun, Seda
AU  - Onaksoy, Ayse bahar
DO  - 10.3906/sag-2004-177
PY  - 2020
JO  - Turkish Journal of Medical Sciences
VL  - 50
IS  - 5
SN  - 1300-0144
SP  - 1428
EP  - 1433
DB  - TRDizin
UR  - http://search/yayin/detay/536102
ER  -