TY  - JOUR
TI  - Prediction of gestational diabetes mellitus in the first
trimester: is it possible?
AB  - Objective: The aim of this study is to identify the first trimester markers that may be associated with gestational diabetes mellitus (GDM) and
to evaluate whether those markers might be used for prediction of gestational diabetes or not.
Methods: Pregnant women between 11 and 14 weeks of gestation applying to the university hospital between August 2018 and March 2019 were
included in the study. Body mass index calculation and blood tests including complete blood count, TSH, T3, T4, HbA1c, uric acid, CRP, procalcitonin,
PAPP-A and β-hCG levels were done during assessment followed by 50 grams of glucose challenge test between the 24 and 28 weeks
of gestation for each woman. Patients with positive results were further evaluated with a 3-hour, 100-g OGTT. According to the diagnostic test
results, the relationship between biochemical markers during the first trimester, BMI and GDM was statistically analyzed.
Results: A hundred and eighty-two pregnant women participated in the study. Fifty-four women had positive glucose challenge test (GCT)
results while 128 women had negative results. Pregnant women with positive GCT results underwent 3-hour, 100-g OGTT and, 24 pregnant
women were diagnosed with GDM, while 158 pregnant women were considered healthy according to the results. There was no statistically significant
difference between GDM and non-GDM groups in terms of age, height, TSH, T3, T4, β-hCG-mom, PAPP-A, PAPP-A-mom, uric
acid and procalcitonin (p>0.05). The mean body weight, body mass index and HbA1c levels were higher and β-hCG levels were lower in the
GDM group compared to the non-GDM group, and these findings were statistically significant (p<0.001).
Conclusion: The use of first trimester markers in GDM prediction seems to have no significance. There is a need for extensive, randomized
studies with universal criteria.
AU  - YÜCEL, NEŞE
AU  - Özdemir, Halis
AU  - hansu, inci
AU  - Hansu, Kemal
DO  - 10.2399/prn.22.0302004
PY  - 2022
JO  - Perinatal journal (Online)
VL  - 30
IS  - 2
SN  - 1305-3124
SP  - 136
EP  - 143
DB  - TRDizin
UR  - http://search/yayin/detay/536148
ER  -