TY  - JOUR
TI  - An evaluation of the results of convalescent plasma therapy applied to pregnant women
diagnosed as COVID-19- positive in a pandemic center: A prospective cohort study
AB  - Background/aim: Convalescent plasma (CP) might be an additional treatment modality in COVID-19. The aim of this study was to
compare CP-related clinical characteristics and perinatal outcomes in pregnant women with mild or moderate-severe COVID-19.
Materials and methods: This prospective cohort study included 36 pregnant women (12 mild and 24 moderate-severe), who underwent
CP therapy. The CP obtained from recently recovered donors was transfused to patients together with maximum supportive care and
antiviral agents. The groups were then compared in respect of clinical characteristics, laboratory parameters, obstetric complications,
and neonatal outcomes.
Results: Significant differences were determined between the groups in respect of systemic corticosteroids in COVID-19 treatment
(41.7%, 87.5%, p = 0.004), oxygen (O2) support (0%, 91.7%, p < 0.001), chest imaging (41.7%, 58.3%, p = 0.02), intensive care unit
admission (0%, 20.8%, p = 0.03) and length of hospitalization (5.5 versus 9.5 days, p < 0.001). The O2 saturation levels before and after
administration of CP were significantly lower in the moderate-severe COVID-19 group (p < 0.05). The O2 therapy time before and after
administration of CP and total O2 therapy time were significantly lower in the mild COVID-19 group (p < 0.05). Platelet, plateletcrit
and lymphocyte counts were significantly higher in both the mild and moderate-severe COVID-19 groups after treatment compared to
the pretreatment values (p < 0.05).
Conclusion: Although data on the results of CP treatment in pregnant women are somewhat limited, it has been suggested that early CP
treatment may be associated with improvements in laboratory and ventilatory parameters in pregnant women with mild and moderatesevere COVID-19. Nevertheless, there is a need for further, randomized controlled studies on this subject with the inclusion of greater
numbers of patients.
AU  - ateş, ihsan
AU  - moraloglu tekin, ozlem
AU  - kucuksahin, orhan
AU  - şahin, Dilek
AU  - erden, abdulsamet
AU  - Omma, Ahmet
AU  - EROL, SEYIT AHMET
AU  - ÜNLÜ, SERPİL
AU  - uyan hendem, derya
AU  - Goncu Ayhan, Sule
AU  - OLUKLU, Deniz
AU  - Tanacan, Atakan
AU  - APAYDIN, HAKAN
DO  - 10.55730/1300-0144.5346
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 3
SN  - 1300-0144
SP  - 554
EP  - 564
DB  - TRDizin
UR  - http://search/yayin/detay/536218
ER  -