Yıl: 2022 Cilt: 52 Sayı: 3 Sayfa Aralığı: 605 - 612 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5352 İndeks Tarihi: 26-07-2022

The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis

Öz:
Background/aim: Hashimoto thyroiditis (HT) is one of the most prevalent autoimmune diseases. The intestine microbiota is strongly associated with autoimmune diseases. Zonulin, a modulator of tight junctions that controls the selective permeability of the intestine can induce an elevation in gut permeability. We aimed to investigate the association of plasma zonulin levels with HT. Materials and methods: We compared 77 HT patients with 66 age-gender and BMI-matched healthy individuals in the case of plasma zonulin levels. Plasma zonulin levels were measured by ELISA. The statistical analyses were performed using Student’s t-test and chisquare tests. The predictive power was investigated using univariate and multivariate logistic regression analysis. Results: We found that the increase in plasma zonulin levels in the HT group was statistically significant compared to the control group (p < 0.001). The regression analysis showed that urea, anti-thyroid peroxidase, aspartate aminotransferase, thyroid-stimulating hormone, free T3, and serum zonulin levels were found to be associated with HT in both univariate and multivariate models (p < 0.05). Conclusion: Zonulin is a possible biomarker candidate that may link intestinal permeability with the etiology of autoimmune diseases.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA demir e, Önal B, Ozkan H, kırac utku i, Sahtiyancı B, Kumbasar A, yenmis g, Demir B (2022). The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. , 605 - 612. 10.55730/1300-0144.5352
Chicago demir esra,Önal Burak,Ozkan Hanise,kırac utku irem,Sahtiyancı Berrak,Kumbasar Abdulbaki,yenmis guven,Demir Bülent The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. (2022): 605 - 612. 10.55730/1300-0144.5352
MLA demir esra,Önal Burak,Ozkan Hanise,kırac utku irem,Sahtiyancı Berrak,Kumbasar Abdulbaki,yenmis guven,Demir Bülent The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. , 2022, ss.605 - 612. 10.55730/1300-0144.5352
AMA demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. . 2022; 605 - 612. 10.55730/1300-0144.5352
Vancouver demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. . 2022; 605 - 612. 10.55730/1300-0144.5352
IEEE demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B "The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis." , ss.605 - 612, 2022. 10.55730/1300-0144.5352
ISNAD demir, esra vd. "The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis". (2022), 605-612. https://doi.org/10.55730/1300-0144.5352
APA demir e, Önal B, Ozkan H, kırac utku i, Sahtiyancı B, Kumbasar A, yenmis g, Demir B (2022). The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. Turkish Journal of Medical Sciences, 52(3), 605 - 612. 10.55730/1300-0144.5352
Chicago demir esra,Önal Burak,Ozkan Hanise,kırac utku irem,Sahtiyancı Berrak,Kumbasar Abdulbaki,yenmis guven,Demir Bülent The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. Turkish Journal of Medical Sciences 52, no.3 (2022): 605 - 612. 10.55730/1300-0144.5352
MLA demir esra,Önal Burak,Ozkan Hanise,kırac utku irem,Sahtiyancı Berrak,Kumbasar Abdulbaki,yenmis guven,Demir Bülent The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. Turkish Journal of Medical Sciences, vol.52, no.3, 2022, ss.605 - 612. 10.55730/1300-0144.5352
AMA demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. Turkish Journal of Medical Sciences. 2022; 52(3): 605 - 612. 10.55730/1300-0144.5352
Vancouver demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis. Turkish Journal of Medical Sciences. 2022; 52(3): 605 - 612. 10.55730/1300-0144.5352
IEEE demir e,Önal B,Ozkan H,kırac utku i,Sahtiyancı B,Kumbasar A,yenmis g,Demir B "The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis." Turkish Journal of Medical Sciences, 52, ss.605 - 612, 2022. 10.55730/1300-0144.5352
ISNAD demir, esra vd. "The relationship between elevated plasma zonulin levels and Hashimoto’s thyroiditis". Turkish Journal of Medical Sciences 52/3 (2022), 605-612. https://doi.org/10.55730/1300-0144.5352