TY  - JOUR
TI  - Assessment of subclinical cardiovascular alterations in nonfunctioning adrenal
incidentalomas
AB  - Background/aim: Adrenal incidentalomas have been associated with increased cardiovascular risk and have a prevalence as high as
10%. This study aims to evaluate carotid- intima media thickness (CIMT), left ventricular mass, and epicardial adipose tissue thickness
in nonfunctioning adrenal incidentaloma patients and compare their results with healthy controls.
Materials and methods: Patients who were referred to the endocrinology clinic for adrenal incidentaloma between 2014 and 2019 were
assessed with 1 mg dexamethasone suppression test, 24-h urine metanephrines and normetanephrines, plasma aldosterone to renin
ratio. Age and gender-matched subjects without an adrenal mass formed the control group. Left ventricular mass, epicardial adipose
tissue thickness, and CIMT of both groups were measured.
Results: A total of 41 adrenal incidentaloma patients (21 female, 52.5%) and 40 healthy controls (19 female, 46.3%) were included in
the study. Patients with adrenal incidentalomas had increased CIMT. No differences were observed in left ventricle mass or epicardial
adipose tissue thickness. There was no correlation between CIMT and adenoma size or serum cortisol (p = 0.2 and p = 0.6, respectively).
There was a statistically significant correlation between CIMT and age (p = 0.016, r = 0.295). HBA1c (p = 0.001) and age (p = 0.05) were
independently associated with CIMT in regression analysis.
Conclusion: Adrenal incidentaloma patients need to be monitored for cardiac dysfunction. CIMT may be used to evaluate adrenal
incidentaloma patients for early cardiovascular risk.
AU  - Can, Bülent
AU  - Telci Caklili, Ozge
AU  - Karaca Özer, Pelin
AU  - Can, Busra
DO  - 10.55730/1300-0144.5360
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 3
SN  - 1300-0144
SP  - 677
EP  - 682
DB  - TRDizin
UR  - http://search/yayin/detay/536366
ER  -