TY  - JOUR
TI  - Mortality related factors on hypoxic ischemic encephalopathic patients treated with
therapeutic hypothermia: an 11-year single-center experience.
AB  - Background/aim: Hypoxic-ischemic encephalopathy (HIE) is a condition that may cause multiple organ dysfunction and has a high
rate of mortality and morbidity. Therapeutic hypothermia is the only proven treatment that decreases the sequel and mortality rate of
neonates that are born after 36 weeks of pregnancy and have moderate-severe HIE.
Material and method: Our study was a single-center, retrospective study that includes newborns (gestational age ≥ 36 weeks) who
underwent therapeutic hypothermia due to hypoxic-ischemic encephalopathy between 2010 and 2020. We evaluated 125 patients who
were diagnosed with moderate to severe HIE and received therapeutic hypothermia. Demographic and clinical data were obtained from
electronic medical records and patient files. The patients were separated into two groups as exitus group (n = 39) and discharged group
(n = 86). We aimed to evaluate factors affecting mortality.
Results: We determined that the median resuscitation times were longer in the delivery room [retrospectively, 10th minutes (0–30) vs. 1
min (0–20), p < 0.05], the tenth min APGAR scores were lower [respectively, 4 (0–7) vs. 6 (3–10), p < 0.05], and the median pH value in
the first blood gas taken was lower [respectively, 6.87 (6.4–7.14) vs. 6.90 (6.58–7.12), p < 0.05] in the exitus group. We also determined
that multiple organ dysfunction is seen more often in the exitus group.
Conclusion: This study demonstrated that the depth of acidosis in the blood gas, multiple organ dysfunction, and the existence of earlyonset seizures are the signs of poor prognosis. Therefore, physicians need to be aware of such prognostic factors to follow these patients
more closely in terms of possible complications and to inform their parents.
AU  - Gökce, ismail Kürşad
AU  - ÖZDEMİR, Ramazan
AU  - DEVECİ, MEHMET FATİH
AU  - Alagöz, Meral
AU  - turgut, hatice
AU  - Kaya, Hüseyin
DO  - 10.55730/1300-0144.5375
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 3
SN  - 1300-0144
SP  - 796
EP  - 802
DB  - TRDizin
UR  - http://search/yayin/detay/536488
ER  -