TY  - JOUR
TI  - Paraoxonase-1 and fetuin-A levels in children with cerebral palsy
AB  - Background/aim: Studies mostly focused on risk factors and clinical status in children with cerebral palsy (CP). Various antiinflammatory
markers may help us in the early diagnosis and clinical classification of cerebral palsy patients. In this study, the relationship between
antiinflammatory marker levels and clinical status in patients with CP is determined. It is the first time that Fetuin-A and Paraoxonase-1
(PON-1) are examined in children with CP.
Materials and methods: The study is conducted on 79 children which are divided into two groups as CP and control. Gross motor
function and spasticity are evaluated in addition to biochemical parameters.
Results: There is a statistically significant difference between CP and control group in terms of PON-1 activity, high sensitive C-Reactive
Protein, HDL, and total cholesterol levels. There is no statistically significant difference in Fetuin A levels between the two groups.
Conclusion: In suspected CP patients less than 24 months of age who possess prenatal and postnatal risk factors, the determination of
PON-1 activity can be considered as a biomarker to support early diagnosis.
AU  - Ignak, Seyda
AU  - güngör, özlem
AU  - Unay Demirel, Ozlem
AU  - Yuksel, Meral
DO  - 10.55730/1300-0144.5376
PY  - 2022
JO  - Turkish Journal of Medical Sciences
VL  - 52
IS  - 3
SN  - 1300-0144
SP  - 803
EP  - 808
DB  - TRDizin
UR  - http://search/yayin/detay/536489
ER  -