Recent advances in organ-on-a-chip technologies and future challenges: a review

EROL, Salim; AVCI, HÜSEYİN; AKPEK, Ali; Doğan Güzel, Fatma

doi:10.3906/kim-1611-35

Recent advances in organ-on-a-chip technologies and future challenges: a review

Hüseyin AVCI, (Eskişehir Osmangazi Üniversitesi, Mühendislik Mimarlık Fakültesi, Metalurji ve Malzeme Mühendisliği Bölümü, Eskişehir, Türkiye)

Fatma DOĞAN GÜZEL, (Ankara Yıldırım Beyazıt Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü, Ankara, Türkiye)

Salim EROL, (Eskişehir Osmangazi Üniversitesi, Mühendislik-Mimarlık Fakültesi, Kimya Mühendisliği Bölümü, Eskişehir, Türkiye)

Ali AKPEK (Harvard-MIT Division of Health Sciences & Technology, Boston, MA, USA)

Turkish Journal of Chemistry

2 0

Yıl: 2018 Cilt: 42 Sayı: 3 Sayfa Aralığı: 587 - 610 Metin Dili: İngilizce DOI: 10.3906/kim-1611-35 İndeks Tarihi: 28-07-2022

Recent advances in organ-on-a-chip technologies and future challenges: a review

Öz:

The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of ‘organ-on-a-chip’ systems. Organon-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development. Only about 1 out of 10,000 compounds is processed in clinical trials for final approval. As being the first example of its kind, in this review, we summarize the current status and future challenges of this new concept that is a promising radical improvement in the drug-monitoring field. In addition, 3D-bioprinting methods used for the construction of organs-on-chips are outlined within the context in order to address the complexities in the field and show the various ways to create these semiartificial hybrid devices using a multidisciplinary approach comprising chemistry, biology, and engineering.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AVCI H, Doğan Güzel F, EROL S, AKPEK A (2018). Recent advances in organ-on-a-chip technologies and future challenges: a review. , 587 - 610. 10.3906/kim-1611-35
Chicago	AVCI HÜSEYİN,Doğan Güzel Fatma,EROL Salim,AKPEK Ali Recent advances in organ-on-a-chip technologies and future challenges: a review. (2018): 587 - 610. 10.3906/kim-1611-35
MLA	AVCI HÜSEYİN,Doğan Güzel Fatma,EROL Salim,AKPEK Ali Recent advances in organ-on-a-chip technologies and future challenges: a review. , 2018, ss.587 - 610. 10.3906/kim-1611-35
AMA	AVCI H,Doğan Güzel F,EROL S,AKPEK A Recent advances in organ-on-a-chip technologies and future challenges: a review. . 2018; 587 - 610. 10.3906/kim-1611-35
Vancouver	AVCI H,Doğan Güzel F,EROL S,AKPEK A Recent advances in organ-on-a-chip technologies and future challenges: a review. . 2018; 587 - 610. 10.3906/kim-1611-35
IEEE	AVCI H,Doğan Güzel F,EROL S,AKPEK A "Recent advances in organ-on-a-chip technologies and future challenges: a review." , ss.587 - 610, 2018. 10.3906/kim-1611-35
ISNAD	AVCI, HÜSEYİN vd. "Recent advances in organ-on-a-chip technologies and future challenges: a review". (2018), 587-610. https://doi.org/10.3906/kim-1611-35

APA	AVCI H, Doğan Güzel F, EROL S, AKPEK A (2018). Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry, 42(3), 587 - 610. 10.3906/kim-1611-35
Chicago	AVCI HÜSEYİN,Doğan Güzel Fatma,EROL Salim,AKPEK Ali Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry 42, no.3 (2018): 587 - 610. 10.3906/kim-1611-35
MLA	AVCI HÜSEYİN,Doğan Güzel Fatma,EROL Salim,AKPEK Ali Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry, vol.42, no.3, 2018, ss.587 - 610. 10.3906/kim-1611-35
AMA	AVCI H,Doğan Güzel F,EROL S,AKPEK A Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry. 2018; 42(3): 587 - 610. 10.3906/kim-1611-35
Vancouver	AVCI H,Doğan Güzel F,EROL S,AKPEK A Recent advances in organ-on-a-chip technologies and future challenges: a review. Turkish Journal of Chemistry. 2018; 42(3): 587 - 610. 10.3906/kim-1611-35
IEEE	AVCI H,Doğan Güzel F,EROL S,AKPEK A "Recent advances in organ-on-a-chip technologies and future challenges: a review." Turkish Journal of Chemistry, 42, ss.587 - 610, 2018. 10.3906/kim-1611-35
ISNAD	AVCI, HÜSEYİN vd. "Recent advances in organ-on-a-chip technologies and future challenges: a review". Turkish Journal of Chemistry 42/3 (2018), 587-610. https://doi.org/10.3906/kim-1611-35